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The PDGF-BB-SOX7 ax...
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages
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- Yang, Yunlong (author)
- Karolinska Institutet
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- Andersson, Patrik (author)
- Karolinska Institutet
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- Hosaka, Kayoko (author)
- Karolinska Institutet
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- Zhang, Yin (author)
- Karolinska Institute, Sweden
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- Cao, Renhai (author)
- Karolinska Institutet
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- Iwamoto, Hideki (author)
- Karolinska Institute, Sweden
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- Yang, Xiaojuan (author)
- Karolinska Institute, Sweden
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- Nakamura, Masaki (author)
- Karolinska Institutet
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- Wang, Jian (author)
- Karolinska Institute, Sweden
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- Zhuang, Rujie (author)
- TCM Hospital Zhejiang Prov, Peoples R China
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- Morikawa, Hiromasa (author)
- Karolinska Institutet
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- Xue, Yuan (author)
- Karolinska Institute, Sweden; MIT, MA 02139 USA
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- Braun, Harald (author)
- University of Ghent, Belgium; Inflammat Research Centre VIB, Belgium
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- Beyaert, Rudi (author)
- University of Ghent, Belgium; Inflammat Research Centre VIB, Belgium
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- Samani, Nilesh (author)
- University of Leicester, England; Glenfield Hospital, England
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- Nakae, Susumu (author)
- University of Tokyo, Japan
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- Hams, Emily (author)
- University of Dublin Trinity Coll, Ireland
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- Dissing, Steen (author)
- University of Copenhagen, Denmark
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- Fallon, Padraic G. (author)
- University of Dublin Trinity Coll, Ireland
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- Langer, Robert (author)
- Karolinska Inst, Stockholm, Sweden, Univ Leicester, Leicester, England, Glenfield Hosp, Leicester, England
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- Cao, Yihai (author)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Karolinska Institute, Sweden; University of Leicester, England; Glenfield Hospital, England
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(creator_code:org_t)
- 2016-05-06
- 2016
- English.
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In: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 7:11385
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https://doi.org/10.1...
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Abstract
Subject headings
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- Signalling molecules and pathways that mediate crosstalk between various tumour cellular compartments in cancer metastasis remain largely unknown. We report a mechanism of the interaction between perivascular cells and tumour-associated macrophages (TAMs) in promoting metastasis through the IL-33-ST2-dependent pathway in xenograft mouse models of cancer. IL-33 is the highest upregulated gene through activation of SOX7 transcription factor in PDGF-BB-stimulated pericytes. Gain-and loss-of-function experiments validate that IL-33 promotes metastasis through recruitment of TAMs. Pharmacological inhibition of the IL-33-ST2 signalling by a soluble ST2 significantly inhibits TAMs and metastasis. Genetic deletion of host IL-33 in mice also blocks PDGF-BB-induced TAM recruitment and metastasis. These findings shed light on the role of tumour stroma in promoting metastasis and have therapeutic implications for cancer therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Yang, Yunlong
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Andersson, Patri ...
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Hosaka, Kayoko
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Zhang, Yin
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Cao, Renhai
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Iwamoto, Hideki
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show more...
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Yang, Xiaojuan
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Nakamura, Masaki
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Wang, Jian
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Zhuang, Rujie
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Morikawa, Hiroma ...
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Xue, Yuan
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Braun, Harald
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Beyaert, Rudi
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Samani, Nilesh
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Nakae, Susumu
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Hams, Emily
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Dissing, Steen
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Fallon, Padraic ...
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Langer, Robert
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Cao, Yihai
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
- Articles in the publication
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Nature Communica ...
- By the university
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Linköping University
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Karolinska Institutet