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  • Lau, Dennis H.University of Adelaide, Australia; Royal Adelaide Hospital, Australia (author)

Novel mechanisms in the pathogenesis of atrial fibrillation: practical applications

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2015-11-17
  • OXFORD UNIV PRESS,2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-129154
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-129154URI
  • https://doi.org/10.1093/eurheartj/ehv375DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:for swepub-publicationtype

Notes

  • Funding Agencies|National Health and Medical Research Council of Australia (NHMRC); University of Adelaide; Lions Medical Research Foundation; Australian Postgraduate Award; Fondation Leducq Structural Alterations in the Myocardium and the Substrate for Cardiac Fibrillation; European Union [EUTRAF-261057]; French National Agency [ANR-10-IAHU-05]; Fondation de France; NHMRC; European Union (FP7 large collaborative project EUTRAF) [261057]; Netherlands Heart Foundation (CVON grant) [2014-09]
  • Intensive research over the last few decades has seen significant advances in our understanding of the complex mechanisms underlying atrial fibrillation (AF). The epidemic of AF and related hospitalizations has been described as a rising tide with estimates of the global AF burden showing no sign of retreat. There is urgency for effective translational programs in this field to facilitate more individualized and targeted therapy to modify the abnormal atrial substrate responsible for the perpetuation of this arrhythmia. In this review, we chose to focus on several novel aspects of AF pathogenesis whereby practical applications in clinical practice are currently available or potentially not too far away. Specifically, we explored the contribution of atrial fibrosis, epicardial adipose tissue, autonomic nervous system, hyper-coagulability, and focal drivers to adverse atrial remodelling and AF persistence. We also highlighted the potential practical means of monitoring and targeting these factors to achieve better outcomes in patients suffering from this debilitating illness. Emerging data also support a new paradigm for targeting AF substrate with aggressive risk factor management. Finally, multi-disciplinary integrated care approach has shown great promise in improving cardiovascular outcomes of patients with AF along with potential cost savings.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Schotten, UlrichMaastricht University, Netherlands (author)
  • Mahajan, RajivUniversity of Adelaide, Australia; Royal Adelaide Hospital, Australia (author)
  • Antic, Nicholas A.Repatriat Gen Hospital, Australia; Flinders University of S Australia, Australia (author)
  • Hatem, Stephane N.Hop La Pitie Salpetriere, France; University of Paris 04, France (author)
  • Pathak, Rajeev K.University of Adelaide, Australia; Royal Adelaide Hospital, Australia (author)
  • Hendriks, JeroenLinköpings universitet,Avdelningen för omvårdnad,Medicinska fakulteten,University of Adelaide, Australia; Royal Adelaide Hospital, Australia(Swepub:liu)jerhe83 (author)
  • Kalman, Jonathan M.Royal Melbourne Hospital, Australia; University of Melbourne, Australia (author)
  • Sanders, PrashanthanUniversity of Adelaide, Australia; Royal Adelaide Hospital, Australia (author)
  • University of Adelaide, Australia; Royal Adelaide Hospital, AustraliaMaastricht University, Netherlands (creator_code:org_t)

Related titles

  • In:European Heart Journal: OXFORD UNIV PRESS37:20, s. 1573-+0195-668X1522-9645

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