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Preproenkephalin mR...
Preproenkephalin mRNA expression in rat parabrachial neurons: relation to cells activated by systemic immune challenge
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- Engström, Linda (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Engblom, David (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Örtegren (Kugelberg), Unn (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Mackerlova, Ludmila (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Paues, Jakob (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Blomqvist, Anders (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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(creator_code:org_t)
- Elsevier Science B.V., Amsterdam. 2001
- 2001
- English.
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In: Neuroscience Letters. - : Elsevier Science B.V., Amsterdam.. - 0304-3940 .- 1872-7972. ; 316:3, s. 165-168
- Related links:
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http://urn.kb.se/res...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- By using a dual-labeling immunohistochemical/in situ hybridization technique we examined if enkephalin-expressing neurons in the pontine parabrachial nucleus, a major brain stem relay for ascending visceral and homeostatic information, were activated by systemic immune challenge. While rats subjected to intravenous injection of bacterial wall lipopolysaccharide expressed dense labeling for the immediate-early gene product FOS in parts of the parabrachial nucleus that also demonstrated dense preproenkephalin expression, only a small proportion of the enkephalin-positive neurons were FOS-positive. These data indicate that enkephalins, although implicated in a variety of autonomic responses, are not primarily involved in the transmission of immune-related information from the parabrachial nucleus to its different forebrain and brain stem targets.
Keyword
- Parabrachial nucleus
- Systemic inflammation
- FOS
- Enkephalin
- In situ hybridization
- Feeding
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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