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  • Philipp Klein, JanMedical University of Lubeck, Germany (author)

Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-05-27
  • KARGER,2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-130322
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-130322URI
  • https://doi.org/10.1159/000445355DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:133800054URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|German Federal Ministry of Health [II A 5-2512 FSB 052]
  • Background: Mild to moderate depressive symptoms are common but often remain unrecognized and treated inadequately. We hypothesized that an Internet intervention in addition to usual care is superior to care as usual alone (CAU) in the treatment of mild to moderate depressive symptoms in adults. Methods: This trial was controlled, randomized and assessor-blinded. Participants with mild to moderate depressive symptoms (Patient Health Questionnaire, PHQ-9, score 5-14) were recruited from clinical and non-clinical set-tings and randomized to either CAU or a 12-week Internet intervention (Deprexis) adjunctive to usual care. Outcomes were assessed at baseline, 3 months (post-assessment) and 6 months (follow-up). The primary outcome measure was self-rated depression severity (PHQ-9). The main analysis was based on the intention-to-treat principle and used linear mixed models. Results: A total of 1,013 participants were randomized. Changes in PHQ-9 from baseline differed significantly between groups (t(825) = 6.12, p amp;lt; 0.001 for the main effect of group). The post-assessment between-group effect size in favour of the intervention was d = 0.39 (95% CI: 0.13-0.64). It was stable at follow-up, with d = 0.32 (95% CI: 0.06-0.69). The rate of participants experiencing at least minimally clinically important PHQ-9 change at the post-assessment was higher in the intervention group (35.6 vs. 20.2%) with a number needed to treat of 7 (95% CI: 5-10). Conclusions: The Internet intervention examined in this trial was superior to CAU alone in reducing mild to moderate depressive symptoms. The magnitude of the effect is clinically important and has public health implications. (C) 2016 S. Karger AG, Basel

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Berger, ThomasUniversity of Bern, Switzerland (author)
  • Schroeder, JohannaUniversity of Medical Centre Hamburg Eppendorf, Germany (author)
  • Spaeth, ChristinaMedical University of Lubeck, Germany (author)
  • Meyer, BjoernGAIA AG, Germany; City University of London, England (author)
  • Caspar, FranzUniversity of Bern, Switzerland (author)
  • Lutz, WolfgangUniversity of Trier, Germany (author)
  • Arndt, AliceUniversity of Trier, Germany (author)
  • Greiner, WolfgangUniversity of Bielefeld, Germany (author)
  • Graefe, ViolaUniversity of Bielefeld, Germany (author)
  • Hautzinger, MartinUniversity of Tubingen, Germany (author)
  • Fuhr, KristinaUniversity of Tubingen, Germany (author)
  • Rose, MatthiasCharite, Germany; University of Massachusetts, MA 01605 USA (author)
  • Nolte, SandraCharite, Germany; Deakin University, Australia (author)
  • Loewe, BerndUniversity of Medical Centre Hamburg Eppendorf, Germany (author)
  • Andersson, GerhardKarolinska Institutet,Linköpings universitet,Psykologi,Filosofiska fakulteten,Karolinska Institute, Sweden(Swepub:liu)geran87 (author)
  • Vettorazzi, EikUniversity of Medical Centre Hamburg Eppendorf, Germany (author)
  • Moritz, SteffenUniversity of Medical Centre Hamburg Eppendorf, Germany (author)
  • Hohagen, FritzMedical University of Lubeck, Germany (author)
  • Medical University of Lubeck, GermanyUniversity of Bern, Switzerland (creator_code:org_t)

Related titles

  • In:Psychotherapy and Psychosomatics: KARGER85:4, s. 218-2280033-31901423-0348

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