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Klinefelters syndro...
Klinefelters syndrome (47,XXY) is in excess among men with Sjogrens syndrome
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- Harris, Valerie M. (author)
- Oklahoma Medical Research Fdn, USA; University of Oklahoma, USA
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- Sharma, Rohan (author)
- University of Oklahoma,USA; Department Vet Affairs Medical Centre, OK USA
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- Cavett, Joshua (author)
- Oklahoma Medical Research Fdn, USA; University of Oklahoma, USA
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- Kurien, Biji T. (author)
- Oklahoma Medical Research Fdn, USA; University of Oklahoma, USA; Department Vet Affairs Medical Centre, OK USA
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- Liu, Ke (author)
- Cincinnati Childrens Hospital Medical Centre, USA; University of Cincinnati, USA
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- Koelsch, Kristi A. (author)
- Oklahoma Medical Research Fdn, USA; University of Oklahoma, USA; Department Vet Affairs Medical Centre, USA
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- Rasmussen, Astrid (author)
- Oklahoma Medical Research Fdn, USA
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- Radfar, Lida (author)
- University of Oklahoma, USA
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- Lewis, David (author)
- University of Oklahoma, USA
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- Stone, Donald U. (author)
- University of Oklahoma, USA; University of Oklahoma, USA
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- Erick Kaufman, C. (author)
- University of Oklahoma, USA
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- Li, Shibo (author)
- University of Oklahoma, USA
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- Segal, Barbara (author)
- University of Minnesota, USA
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- Wallace, Daniel J. (author)
- Cedars Sinai Medical Centre, USA
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- Weisman, Michael H. (author)
- Cedars Sinai Medical Centre, USA
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- Venuturupalli, Swamy (author)
- Cedars Sinai Medical Centre, USA
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- Kelly, Jennifer A. (author)
- Oklahoma Medical Research Fdn, USA
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- Alarcon-Riquelme, Marta E. (author)
- Karolinska Institutet,Oklahoma Medical Research Fdn, USA; University of Granada, Spain
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- Pons-Estel, Bernardo (author)
- Sanat Parque, Argentina
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- Jonsson, Roland (author)
- University of Bergen, Norway; Haukeland Hospital, Norway
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- Lu, Xianglan (author)
- University of Oklahoma, USA
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- Gottenberg, Jacques-Eric (author)
- Strasbourg University, France
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- Anaya, Juan-Manuel (author)
- University of Rosario, Colombia
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- Cunninghame-Graham, Deborah S. (author)
- Kings Coll London, England
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- Huang, Andrew J. W. (author)
- University of Minnesota, USA
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- Brennan, Michael T. (author)
- Carolinas Medical Centre, USA
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- Hughes, Pamela (author)
- University of Minnesota, MN USA
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- Alevizos, Ilias (author)
- National Institute Dent and Craniofacial Research, MD USA
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- Miceli-Richard, Corinne (author)
- University of Paris 11, France
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- Keystone, Edward C. (author)
- Mt Sinai Hospital, Canada; University of Toronto, Canada
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- Bykerk, Vivian P. (author)
- Hospital Special Surg, NY USA
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- Hirschfield, Gideon (author)
- University of Birmingham, England
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- Xie, Gang (author)
- University of Toronto, Canada
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- Ng, Wan-Fai (author)
- Newcastle University, England
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- Nordmark, Gunnel (author)
- Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab
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- Magnusson Bucher, Sara (author)
- Örebro University Hospital, Sweden
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- Eriksson, Per (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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- Omdal, Roald (author)
- Stavanger University Hospital, Norway
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- Rhodus, Nelson L. (author)
- University of Minnesota, USA
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- Rischmueller, Maureen (author)
- Queen Elizabeth Hospital, Australia; University of Adelaide, Australia
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- Rohrer, Michael (author)
- University of Minnesota, USA
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- Wahren-Herlenius, Marie (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Witte, Torsten (author)
- Hannover Medical Sch, Germany
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- Mariette, Xavier (author)
- University of Paris 11, France
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- Lessard, Christopher J. (author)
- Oklahoma Medical Research Fdn, USA
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- Harley, John B. (author)
- Cincinnati Childrens Hospital Medical Centre, USA; University of Cincinnati, OH USA; Department Vet Affairs Medical Centre, OH USA
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- Sivils, Kathy L. (author)
- Oklahoma Medical Research Fdn, USA; University of Oklahoma, OK 73190 USA
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- Scofield, R. Hal (author)
- Oklahoma Medical Research Fdn, USA; University of Oklahoma, OK 73190 USA; University of Oklahoma, OK 73190 USA; Department Vet Affairs Medical Centre, OK USA
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(creator_code:org_t)
- ACADEMIC PRESS INC ELSEVIER SCIENCE, 2016
- 2016
- English.
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In: Clinical Immunology. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 1521-6616 .- 1521-7035. ; 168, s. 25-29
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Primary Sjogrens syndrome (pSS) has a strong female bias. We evaluated an X chromosome dose effect by analyzing 47,XXY (Klinefelters syndrome, 1 in 500 live male births) among subjects with pSS. 47,XXY was determined by examination of fluorescence intensity of single nucleotide polymorphisms from the X and Y chromosomes. Among 136 pSS men there were 4 with 47,XXY. This was significantly different from healthy controls (1 of 1254 had 47)0(Y, p = 0.0012 by Fishers exact test) as well men with rheumatoid arthritis (0 of 363 with 47,XXY), but not different compared to men with systemic lupus erythematosus (SLE) (4 of 136 versus 8 of 306, Fishers exact test p = NS). These results are consistent with the hypothesis that the number of X chromosomes is critical for the female bias of pSS, a property that may be shared with SLE but not RA. Published by Elsevier Inc.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Sjogrens syndrome; X chromosome; Klinefelters syndrome; Sex bias
- Medical Science
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Harris, Valerie ...
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Sharma, Rohan
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Cavett, Joshua
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Kurien, Biji T.
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Liu, Ke
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Koelsch, Kristi ...
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show more...
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Rasmussen, Astri ...
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Radfar, Lida
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Lewis, David
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Stone, Donald U.
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Erick Kaufman, C ...
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Li, Shibo
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Segal, Barbara
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Wallace, Daniel ...
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Weisman, Michael ...
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Venuturupalli, S ...
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Kelly, Jennifer ...
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Alarcon-Riquelme ...
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Pons-Estel, Bern ...
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Jonsson, Roland
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Lu, Xianglan
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Gottenberg, Jacq ...
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Anaya, Juan-Manu ...
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Cunninghame-Grah ...
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Huang, Andrew J. ...
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Brennan, Michael ...
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Hughes, Pamela
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Alevizos, Ilias
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Miceli-Richard, ...
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Keystone, Edward ...
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Bykerk, Vivian P ...
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Hirschfield, Gid ...
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Xie, Gang
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Ng, Wan-Fai
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Nordmark, Gunnel
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Magnusson Bucher ...
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Eriksson, Per
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Omdal, Roald
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Rhodus, Nelson L ...
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Rischmueller, Ma ...
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Rohrer, Michael
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Wahren-Herlenius ...
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Witte, Torsten
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Mariette, Xavier
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Lessard, Christo ...
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Harley, John B.
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Sivils, Kathy L.
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Scofield, R. Hal
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Clinical Immunol ...
- By the university
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Linköping University
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Karolinska Institutet
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Uppsala University