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  • Harris, Valerie M.Oklahoma Medical Research Fdn, USA; University of Oklahoma, USA (author)

Klinefelters syndrome (47,XXY) is in excess among men with Sjogrens syndrome

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • ACADEMIC PRESS INC ELSEVIER SCIENCE,2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-130838
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-130838URI
  • https://doi.org/10.1016/j.clim.2016.04.002DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:133968545URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-300374URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|NIH [AR053483, AI082714, AR053734, GM104938]; US Department of Veterans Affairs
  • Primary Sjogrens syndrome (pSS) has a strong female bias. We evaluated an X chromosome dose effect by analyzing 47,XXY (Klinefelters syndrome, 1 in 500 live male births) among subjects with pSS. 47,XXY was determined by examination of fluorescence intensity of single nucleotide polymorphisms from the X and Y chromosomes. Among 136 pSS men there were 4 with 47,XXY. This was significantly different from healthy controls (1 of 1254 had 47)0(Y, p = 0.0012 by Fishers exact test) as well men with rheumatoid arthritis (0 of 363 with 47,XXY), but not different compared to men with systemic lupus erythematosus (SLE) (4 of 136 versus 8 of 306, Fishers exact test p = NS). These results are consistent with the hypothesis that the number of X chromosomes is critical for the female bias of pSS, a property that may be shared with SLE but not RA. Published by Elsevier Inc.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sharma, RohanUniversity of Oklahoma,USA; Department Vet Affairs Medical Centre, OK USA (author)
  • Cavett, JoshuaOklahoma Medical Research Fdn, USA; University of Oklahoma, USA (author)
  • Kurien, Biji T.Oklahoma Medical Research Fdn, USA; University of Oklahoma, USA; Department Vet Affairs Medical Centre, OK USA (author)
  • Liu, KeCincinnati Childrens Hospital Medical Centre, USA; University of Cincinnati, USA (author)
  • Koelsch, Kristi A.Oklahoma Medical Research Fdn, USA; University of Oklahoma, USA; Department Vet Affairs Medical Centre, USA (author)
  • Rasmussen, AstridOklahoma Medical Research Fdn, USA (author)
  • Radfar, LidaUniversity of Oklahoma, USA (author)
  • Lewis, DavidUniversity of Oklahoma, USA (author)
  • Stone, Donald U.University of Oklahoma, USA; University of Oklahoma, USA (author)
  • Erick Kaufman, C.University of Oklahoma, USA (author)
  • Li, ShiboUniversity of Oklahoma, USA (author)
  • Segal, BarbaraUniversity of Minnesota, USA (author)
  • Wallace, Daniel J.Cedars Sinai Medical Centre, USA (author)
  • Weisman, Michael H.Cedars Sinai Medical Centre, USA (author)
  • Venuturupalli, SwamyCedars Sinai Medical Centre, USA (author)
  • Kelly, Jennifer A.Oklahoma Medical Research Fdn, USA (author)
  • Alarcon-Riquelme, Marta E.Karolinska Institutet,Oklahoma Medical Research Fdn, USA; University of Granada, Spain (author)
  • Pons-Estel, BernardoSanat Parque, Argentina (author)
  • Jonsson, RolandUniversity of Bergen, Norway; Haukeland Hospital, Norway (author)
  • Lu, XianglanUniversity of Oklahoma, USA (author)
  • Gottenberg, Jacques-EricStrasbourg University, France (author)
  • Anaya, Juan-ManuelUniversity of Rosario, Colombia (author)
  • Cunninghame-Graham, Deborah S.Kings Coll London, England (author)
  • Huang, Andrew J. W.University of Minnesota, USA (author)
  • Brennan, Michael T.Carolinas Medical Centre, USA (author)
  • Hughes, PamelaUniversity of Minnesota, MN USA (author)
  • Alevizos, IliasNational Institute Dent and Craniofacial Research, MD USA (author)
  • Miceli-Richard, CorinneUniversity of Paris 11, France (author)
  • Keystone, Edward C.Mt Sinai Hospital, Canada; University of Toronto, Canada (author)
  • Bykerk, Vivian P.Hospital Special Surg, NY USA (author)
  • Hirschfield, GideonUniversity of Birmingham, England (author)
  • Xie, GangUniversity of Toronto, Canada (author)
  • Ng, Wan-FaiNewcastle University, England (author)
  • Nordmark, GunnelUppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)gunnnord (author)
  • Magnusson Bucher, SaraÖrebro University Hospital, Sweden (author)
  • Eriksson, PerLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland(Swepub:liu)perer22 (author)
  • Omdal, RoaldStavanger University Hospital, Norway (author)
  • Rhodus, Nelson L.University of Minnesota, USA (author)
  • Rischmueller, MaureenQueen Elizabeth Hospital, Australia; University of Adelaide, Australia (author)
  • Rohrer, MichaelUniversity of Minnesota, USA (author)
  • Wahren-Herlenius, MarieKarolinska Institutet,Karolinska Institute, Sweden (author)
  • Witte, TorstenHannover Medical Sch, Germany (author)
  • Mariette, XavierUniversity of Paris 11, France (author)
  • Lessard, Christopher J.Oklahoma Medical Research Fdn, USA (author)
  • Harley, John B.Cincinnati Childrens Hospital Medical Centre, USA; University of Cincinnati, OH USA; Department Vet Affairs Medical Centre, OH USA (author)
  • Sivils, Kathy L.Oklahoma Medical Research Fdn, USA; University of Oklahoma, OK 73190 USA (author)
  • Scofield, R. HalOklahoma Medical Research Fdn, USA; University of Oklahoma, OK 73190 USA; University of Oklahoma, OK 73190 USA; Department Vet Affairs Medical Centre, OK USA (author)
  • Oklahoma Medical Research Fdn, USA; University of Oklahoma, USAUniversity of Oklahoma,USA; Department Vet Affairs Medical Centre, OK USA (creator_code:org_t)

Related titles

  • In:Clinical Immunology: ACADEMIC PRESS INC ELSEVIER SCIENCE168, s. 25-291521-66161521-7035

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