Bioelectronic neural pixel: Chemical stimulation and electrical sensing at the same site

Jonsson, Amanda (author): Linköpings universitet,Fysik och elektroteknik,Tekniska fakulteten

Inal, Sahika (author): Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, Gardanne, France

Uguz, Ilke (author): Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, Gardanne, France

Williamson, Adam (author): Aix Marseille Université, INS, Marseille, France; Inserm, UMR_S 1106, Marseille, France

Kergoat, Loig (author): Linköpings universitet,Fysik och elektroteknik,Tekniska fakulteten,Aix Marseille Université, INS, Marseille, France; Inserm, UMR_S 1106, Marseille, France

Rivnay, Jonathan (author): Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, Gardanne, France

Khodagholy, Dion (author): Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, Gardanne, France

Berggren, Magnus (author): Linköpings universitet,Fysik och elektroteknik,Tekniska fakulteten

Bernard, Christophe (author): Aix Marseille Université, INS, Marseille, France; Inserm, UMR_S 1106, Marseille, France

Malliaras, George G (author): Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, Gardanne, France

Simon, Daniel T (author): Linköpings universitet,Fysik och elektroteknik,Tekniska fakulteten

(creator_code:org_t)

2016-08-09
2016
English.
In: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 113:34, s. 9440-9445

Related links:: https://liu.diva-por... (primary) (Raw object); show more...; https://www.pnas.org...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Abstract Subject headings

Local control of neuronal activity is central to many therapeutic strategies aiming to treat neurological disorders. Arguably, the best solution would make use of endogenous highly localized and specialized regulatory mechanisms of neuronal activity, and an ideal therapeutic technology should sense activity and deliver endogenous molecules at the same site for the most efficient feedback regulation. Here, we address this challenge with an organic electronic multifunctional device that is capable of chemical stimulation and electrical sensing at the same site, at the single-cell scale. Conducting polymer electrodes recorded epileptiform discharges induced in mouse hippocampal preparation. The inhibitory neurotransmitter, γ-aminobutyric acid (GABA), was then actively delivered through the recording electrodes via organic electronic ion pump technology. GABA delivery stopped epileptiform activity, recorded simultaneously and colocally. This multifunctional “neural pixel” creates a range of opportunities, including implantable therapeutic devices with automated feedback, where locally recorded signals regulate local release of specific therapeutic agents.

By the author/editor: Jonsson, Amanda; Inal, Sahika; Uguz, Ilke; Williamson, Adam; Kergoat, Loig; Rivnay, Jonathan; show more...; Khodagholy, Dion; Berggren, Magnus; Bernard, Christo ...; Malliaras, Georg ...; Simon, Daniel T; show less...

About the subject

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