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Bioelectronic neura...
Bioelectronic neural pixel: Chemical stimulation and electrical sensing at the same site
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- Jonsson, Amanda (author)
- Linköpings universitet,Fysik och elektroteknik,Tekniska fakulteten
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- Inal, Sahika (author)
- Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, Gardanne, France
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- Uguz, Ilke (author)
- Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, Gardanne, France
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- Williamson, Adam (author)
- Aix Marseille Université, INS, Marseille, France; Inserm, UMR_S 1106, Marseille, France
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- Kergoat, Loig (author)
- Linköpings universitet,Fysik och elektroteknik,Tekniska fakulteten,Aix Marseille Université, INS, Marseille, France; Inserm, UMR_S 1106, Marseille, France
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- Rivnay, Jonathan (author)
- Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, Gardanne, France
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- Khodagholy, Dion (author)
- Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, Gardanne, France
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- Berggren, Magnus (author)
- Linköpings universitet,Fysik och elektroteknik,Tekniska fakulteten
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- Bernard, Christophe (author)
- Aix Marseille Université, INS, Marseille, France; Inserm, UMR_S 1106, Marseille, France
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- Malliaras, George G (author)
- Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, Gardanne, France
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- Simon, Daniel T (author)
- Linköpings universitet,Fysik och elektroteknik,Tekniska fakulteten
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(creator_code:org_t)
- 2016-08-09
- 2016
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 113:34, s. 9440-9445
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https://liu.diva-por... (primary) (Raw object)
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https://www.pnas.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Local control of neuronal activity is central to many therapeutic strategies aiming to treat neurological disorders. Arguably, the best solution would make use of endogenous highly localized and specialized regulatory mechanisms of neuronal activity, and an ideal therapeutic technology should sense activity and deliver endogenous molecules at the same site for the most efficient feedback regulation. Here, we address this challenge with an organic electronic multifunctional device that is capable of chemical stimulation and electrical sensing at the same site, at the single-cell scale. Conducting polymer electrodes recorded epileptiform discharges induced in mouse hippocampal preparation. The inhibitory neurotransmitter, γ-aminobutyric acid (GABA), was then actively delivered through the recording electrodes via organic electronic ion pump technology. GABA delivery stopped epileptiform activity, recorded simultaneously and colocally. This multifunctional “neural pixel” creates a range of opportunities, including implantable therapeutic devices with automated feedback, where locally recorded signals regulate local release of specific therapeutic agents.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Elektroteknik och elektronik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Electrical Engineering, Electronic Engineering, Information Engineering (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Jonsson, Amanda
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Inal, Sahika
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Uguz, Ilke
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Williamson, Adam
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Kergoat, Loig
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Rivnay, Jonathan
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show more...
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Khodagholy, Dion
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Berggren, Magnus
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Bernard, Christo ...
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Malliaras, Georg ...
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Simon, Daniel T
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- About the subject
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Electrical Engin ...
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Proceedings of t ...
- By the university
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Linköping University