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Levodopa-carbidopa ...
Levodopa-carbidopa intestinal gel (LCIG) treatment in routine care of patients with advanced Parkinsons disease: An open-label prospective observational study of effectiveness, tolerability and healthcare costs
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- Pålhagen, Sven E. (author)
- Karolinska University Hospital, Sweden,Karolinska Univ Hosp, Dept Neurol, SE-14186 Stockholm, Sweden
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- Sydow, Olof (author)
- Karolinska University Hospital, Sweden,Karolinska Univ Hosp, Dept Neurol, SE-14186 Stockholm, Sweden
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- Johansson, Anders (author)
- Uppsala universitet,Karolinska Institutet,Neurologi
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- Nyholm, Dag (author)
- Uppsala universitet,Neurologi
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- Holmberg, Bjorn (author)
- Sahlgrens University Hospital, Sweden,Sahlgrens Univ Hosp, Dept Clin Neurosci, Gothenburg, Sweden
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- Widner, Hakan (author)
- Skåne University Hospital, Sweden,Skane Univ Hosp, Dept Neurol, Lund, Sweden
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- Dizdar Segrell, Nil (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping,Linkoping Univ, Dept Neurol, Linkoping, Sweden; Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden
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- Linder, Jan (author)
- Norrlands University Hospital, Sweden,Norrlands Univ Hosp, Neuroctr, Dept Neurol, Umea, Sweden
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- Hauge, Tove (author)
- Molde Hospital HNR, Norway,Molde Hosp HNR, Dept Neurol, Molde, Norway
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- Jansson, Rasmus (author)
- Sundsvall Hospital, Sweden,Sundsvall Hosp, Dept Geriatr Med & Rehabil, Sundsvall, Sweden
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- Bergmann, Lars (author)
- AbbVie Inc, N Chicago, IL USA
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- Kjellander, Susanna (author)
- AbbVie AB, Solna, Sweden
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- Marshall, Thomas S. (author)
- AbbVie Inc, N Chicago, IL USA
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(creator_code:org_t)
- ELSEVIER SCI LTD, 2016
- 2016
- English.
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In: Parkinsonism & Related Disorders. - : ELSEVIER SCI LTD. - 1353-8020 .- 1873-5126. ; 29, s. 17-23
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Abstract
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- Background: Continuous infusion of levodopa-carbidopa intestinal gel (LCIG) can effectively manage motor and non-motor complications in advanced Parkinsons disease (PD). Healthcare costs, quality of life (QoL), effectiveness, and tolerability were assessed in routine care treatment with LCIG. Methods: The seventy-seven patients enrolled in this prospective, open-label, 3-year study in routine medical care were LCIG-naive (N = 37), or had previous LCIG treatment for amp;lt;2 (N = 22), or amp;gt;= 2 (N = 18) years. Healthcare costs were collected monthly. PD symptoms and QoL were assessed with the Unified Parkinsons Disease Rating Scale (UPDRS), 39-item Parkinsons Disease Questionnaire (PDQ-39), and EuroQoL 5-Dimension Visual Analog Scale (EQ-5D VAS); LCIG dose, safety, and tolerability were monitored. Results: Mean monthly costs per patient ( 8226 5952) were similar across cohorts, remained steady during 3-year follow-up, and increased with PD severity and QoL impairment. In LCIG-naive patients, significant improvements compared to baseline were observed on the UPDRS total score and PDQ-39 summary index score through 18 months (n = 24; UPDRS, p = 0.033; PDQ-39, p = 0.049). Symptom control was maintained during 3-year follow-up in LCIG-experienced cohorts. Small changes in mean daily LCIG dose were observed. Adverse events were common and generally related to the device, procedure, levodopa, or laboratory evaluations. Conclusions: Costs in LCIG-treated patients were stable over 3 years. LCIG treatment led to significant improvements in motor function and QoL over 18 months in LCIG-naive patients and no worsening was observed in LCIG-experienced patients over 3 years despite natural PD progression over time. The longterm safety was consistent with the established LCIG profile. (C) 2016 AbbVie Inc. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Parkinsons disease; Levodopa; Infusion; LCIG; Cost
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Pålhagen, Sven E ...
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Sydow, Olof
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Johansson, Ander ...
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Nyholm, Dag
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Holmberg, Bjorn
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Widner, Hakan
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Dizdar Segrell, ...
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Linder, Jan
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Hauge, Tove
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Jansson, Rasmus
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Bergmann, Lars
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Kjellander, Susa ...
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Marshall, Thomas ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Parkinsonism & R ...
- By the university
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Linköping University
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Karolinska Institutet
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Uppsala University