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Cathepsin D mediate...
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Johansson, Ann-CharlotteLinköpings universitet,Experimentell patologi,Hälsouniversitetet
(författare)
Cathepsin D mediates cytochrome c release and caspase activation in human fibroblast apoptosis induced by staurosporine
- Artikel/kapitelEngelska2003
Förlag, utgivningsår, omfång ...
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2003-10-24
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Springer Science and Business Media LLC,2003
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-13200
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-13200URI
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https://doi.org/10.1038/sj.cdd.4401290DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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There is increasing evidence that proteases other than caspases, for example, the lysosomal cathepsins B, D and L, are involved in apoptotic cell death. In the present study, we present data that suggest a role for cathepsin D in staurosporine-induced apoptosis in human foreskin fibroblasts. Cathepsin D and cytochrome c were detected partially released to the cytosol after exposure to 0.1 µM staurosporine for 1 h. After 4 h, activation of caspase-9 and -3 was initiated and later caspase-8 activation and a decrease in full-length Bid were detected. Pretreatment of cells with the cathepsin D inhibitor, pepstatin A, prevented cytochrome c release and caspase activation, and delayed cell death. These results imply that cytosolic cathepsin D is a key mediator in staurosporine-induced apoptosis. Analysis of the relative sequence of apoptotic events indicates that, in this cell type, cathepsin D acts upstream of cytochrome c release and caspase activation.
Ämnesord och genrebeteckningar
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apoptosis
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caspases
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cathepsin D
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cytochrome c
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fibroblasts
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lysosomes
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Steen, Håkan
(författare)
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Öllinger, KarinÖstergötlands Läns Landsting,Linköpings universitet,Experimentell patologi,Hälsouniversitetet,Klinisk patologi och klinisk genetik(Swepub:liu)karol56
(författare)
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Roberg, KarinÖstergötlands Läns Landsting,Linköpings universitet,Oto-Rhino-Laryngologi,Hälsouniversitetet,Öronkliniken US(Swepub:liu)karro26
(författare)
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Linköpings universitetExperimentell patologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cell Death and Differentiation: Springer Science and Business Media LLC10:11, s. 1253-12591350-90471476-5403
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