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  • Wang, PengCapital Medical University, Peoples R China; Logist University of Peoples Armed Police Force, Peoples R China (author)

Depression-like behavior in rat: Involvement of galanin receptor subtype 1 in the ventral periaqueductal gray

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-07-25
  • NATL ACAD SCIENCES,2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-132490
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-132490URI
  • https://doi.org/10.1073/pnas.1609198113DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:134376450URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|National Natural Sciences Foundation of China [30870815, 31171032]; Beijing Natural Science Foundation [7091002]; National Basic Research Program of China 973 Program [2010CB912003]; Beijing Talent Project [PHR20100510]; Swedish Research Council [4X-2887]; Seed Grant of the International Alliance of Translational Neuroscience [PXM2014_014226_000006]; Beijing Brain Project [Z161100000216142]; KI
  • The neuropeptide galanin coexists in rat brain with serotonin in the dorsal raphe nucleus and with noradrenaline in the locus coeruleus (LC), and it has been suggested to be involved in depression. We studied rats exposed to chronic mild stress (CMS), a rodent model of depression. As expected, these rats showed several endophenotypes relevant to depression-like behavior compared with controls. All these endophenotypes were normalized after administration of a selective serotonin reuptake inhibitor. The transcripts for galanin and two of its receptors, galanin receptor 1 (GALR1) and GALR2, were analyzed with quantitative real-time PCR using laser capture microdissection in the following brain regions: the hippocampal formation, LC, and ventral periaqueductal gray (vPAG). Only Galr1 mRNA levels were significantly increased, and only in the latter region. After knocking down Galr1 in the vPAG with an siRNA technique, all parameters of the depressive behavioral phenotype were similar to controls. Thus, the depression-like behavior in rats exposed to CMS is likely related to an elevated expression of Galr1 in the vPAG, suggesting that a GALR1 antagonist could have antidepressant effects.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Li, HuiCapital Medical University, Peoples R China (author)
  • Barde, SwapnaliKarolinska Institutet,Karolinska Institute, Sweden (author)
  • Zhang, Ming-DongKarolinska Institutet,Karolinska Institute, Sweden; Karolinska Institute, Sweden (author)
  • Sun, JingCapital Medical University, Peoples R China (author)
  • Wang, TongCapital Medical University, Peoples R China (author)
  • Zhang, PanCapital Medical University, Peoples R China (author)
  • Luo, HanjiangCapital Medical University, Peoples R China (author)
  • Wang, YongjunCapital Medical University, Peoples R China (author)
  • Yang, YutaoCapital Medical University, Peoples R China (author)
  • Wang, ChuanyueCapital Medical University, Peoples R China (author)
  • Svenningsson, PerKarolinska Institutet,Karolinska Institute, Sweden; Karolinska University Hospital, Sweden (author)
  • Theodorsson, ElvarLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Region Östergötland, Klinisk kemi(Swepub:liu)elvth65 (author)
  • Hokfelt, Tomas G. M.Karolinska Institute, Sweden (author)
  • David Xu, Zhi-QingKarolinska Institutet,Capital Medical University, Peoples R China (author)
  • Capital Medical University, Peoples R China; Logist University of Peoples Armed Police Force, Peoples R ChinaCapital Medical University, Peoples R China (creator_code:org_t)

Related titles

  • In:Proceedings of the National Academy of Sciences of the United States of America: NATL ACAD SCIENCES113:32, s. E4726-E47350027-84241091-6490

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