Sökning: onr:"swepub:oai:DiVA.org:liu-133518" >
Cardiac and stem ce...
Cardiac and stem cell-cocooned hybrid microspheres: A multi factorial design approach
-
- Sherrell, Peter (författare)
- Linköpings universitet,Biomedicinsk instrumentteknik,Tekniska högskolan
-
- Elmén, Karin (författare)
- Linköpings universitet,Institutionen för medicinsk teknik,Tekniska fakulteten
-
- Cieslar-Pobuda, Artur (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Silesian Technical University, Poland
-
visa fler...
-
- Wiechec, Emilia (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten
-
- Lemoine, Mark (författare)
- Linköpings universitet,Institutionen för medicinsk teknik,Tekniska fakulteten
-
- Arzhangi, Zahra (författare)
- University of Ottawa, Canada
-
- Silverå Ejneby, Malin (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
-
- Brask, Johan (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
-
- Daka, Joseph N. (författare)
- Health Canada, Canada
-
- Rafat, Mehrdad (författare)
- Linköpings universitet,Biomedicinsk instrumentteknik,Tekniska fakulteten,Health Canada, Canada; LinkoCare Life Science AB, Linkoping, Sweden
-
visa färre...
-
(creator_code:org_t)
- ELSEVIER SCIENCE SA, 2016
- 2016
- Engelska.
-
Ingår i: Sensors and actuators. B, Chemical. - : ELSEVIER SCIENCE SA. - 0925-4005 .- 1873-3077. ; 236, s. 480-489
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Cell therapy is a promising approach for the treatment of patients suffering from myocardial infarction. Most recent therapies involve direct injection of cells into the damaged heart tissue to induce regeneration and help restore its functions, however, anoikis and the harsh environment at the sight of injection limit the therapeutic efficacy of current techniques. Biopolymeric microspheres such as alginate have been widely used for cells encapsulation and delivery for cell therapy applications. However, majority of these techniques are not standardized that is a big challenge for translation into clinically-relevant treatment options. In addition, purely-alginate base microspheres are limited by poor biodegradability and lack of strong interaction between the encapsulated cells and their surrounding alginate matrix. In this work, we have shown that the addition of type I collagen into alginate microspheres, systematically optimized by a multivariate experimental design, improves the biocompatibility of the microspheres towards induced pluripotent stem cells (iPS), cardiomyocytes, and blood outgrowth endothelial cells (BOEC), whilst improving diffusion between outside environment and the inner sphere. The addition of collagen allows for multiple routes for sphere degradation leading to potentially greater control over cell release once delivered. Mathematical models were developed and utilized to effectively evaluate and predict the influence of various factors such as polymer ratios, micronization air flow rate, and air-gap distance on spheres size and shape, which play a key role in cell viability, degradation rate of microspheres, as well as controlled production of the cell cocoons toward clinically-relevant cell therapies for treatment of myocardial infarction. (C) 2016 Elsevier B.V. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
Nyckelord
- Myocardial infarction; Cell therapy; Cell encapsulation; Induced pluripotent stem cells; Collagen; Multivariate factorial design
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Sherrell, Peter
-
Elmén, Karin
-
Cieslar-Pobuda, ...
-
Wiechec, Emilia
-
Lemoine, Mark
-
Arzhangi, Zahra
-
visa fler...
-
Silverå Ejneby, ...
-
Brask, Johan
-
Daka, Joseph N.
-
Rafat, Mehrdad
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinsk biotek ...
-
och Biomedicinsk lab ...
- Artiklar i publikationen
-
Sensors and actu ...
- Av lärosätet
-
Linköpings universitet