Search: onr:"swepub:oai:DiVA.org:liu-133695" >
Ki-67 expression pr...
Ki-67 expression predicts locoregional recurrence in stage I oral tongue carcinoma.
-
- Wangsa, D (author)
- Karolinska Institutet
-
- Ryott, M (author)
- Karolinska Institutet
-
- Åvall-Lundqvist, Elisabeth (author)
- Karolinska Institutet
-
show more...
-
- Petersson, F (author)
- Department of Oncology-Pathology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
-
- Elmberger, G (author)
- Karolinska Institutet
-
- Luo, J (author)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
-
- Ried, T (author)
- Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
-
- Auer, G (author)
- Karolinska Institutet
-
- Munck-Wikland, E (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- 2008-09-02
- 2008
- English.
-
In: British Journal of Cancer. - : Nature Publishing Group. - 0007-0920 .- 1532-1827. ; 99:7, s. 1121-1128
- Related links:
-
https://www.nature.c...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Oral tongue squamous cell carcinoma (OTSCC) is an aggressive cancer associated with poor prognosis. Methods for determining the aggressiveness of OTSCC from analysis of the primary tumour specimen are thus highly desirable. We investigated whether genomic instability and proliferative activity (by means of Ki-67 activity) could be of clinical use for prediction of locoregional recurrence in 76 pretreatment OTSCC paraffin samples (stage I, n=22; stage II, n=33; stage III, n=8; stage IV, n=13). Eleven surgical tumour specimens were also analysed for remnants of proliferative activity after preoperative radiotherapy. Ninety-seven percent of cases (n=72) were characterised as being aneuploid as measured by means of image cytometry. Preoperative radiotherapy (50-68 Gy) resulted in significant reduction of proliferative activity in all patients for which post-treatment biopsies were available (P-value=0.001). Proliferative activity was not associated with response to radiation in stage II patients. However, we report a significant correlation between high proliferation rates and locoregional recurrences in stage I OTSCC patients (P-value=0.028). High-proliferative activity is thus related to an elevated risk of recurrence after surgery alone. We therefore conclude that Ki-67 expression level is a potentially useful clinical marker for predicting recurrence in surgically treated stage I OTSCC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- oral cancer
- Ki-67
- locoregional recurrence
- ploidy
- genomic instability
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database