Overexpression of Psoriasin (S100A7) Contributes to Dysregulated Differentiation in Psoriasis.

Ekman, Anna-KarinLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Hudkliniken i Östergötland,Ingrid Asp Psoriasis Research Center (author)

Funding agencies: Ingrid Asp Foundation; Welander Foundation; Swedish psoriasis association; Medical Research Council
Psoriasin, which is highly expressed in psoriasis, is encoded by a gene located within the epidermal differentiation complex. The aim of this study was to investigate the effect of endogenous psoriasin on disturbed keratinocyte differentiation in psoriasis. Immunohistochemical staining revealed a gradient of psoriasin expression in the psoriatic epidermis with highest expression in the suprabasal, differentiated layers. Induction of keratinocyte differentiation caused concurrent expression of psoriasin and the differentiation marker involucrin. The differentiation-induced psoriasin expression was found to be mediated by the protein kinase C pathway. The downregulation of psoriasin expression by small interfering RNA revealed that psoriasin mediates the expression of involucrin, desmoglein 1, transglutaminase 1 and CD24 in normal differentiation. The lentivirus-mediated overexpression of psoriasin, mimicking the psoriatic milieu, gave rise to an altered regulation of differentiation genes and an expression pattern reminiscent of that in psoriatic epidermis. These findings suggest that psoriasin contributes to the dysregulated differentiation process in the psoriasis epidermis.

Vegfors, JennyLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Hudkliniken i Östergötland,Ingrid Asp Psoriasis Research Center(Swepub:liu)jenni01 (author)
Bivik, Cecilia,1978-Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Ingrid Asp Psoriasis Research Center(Swepub:liu)cecbi55 (author)
Enerbäck, Charlotta,1965-Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Hudkliniken i Östergötland,Ingrid Asp Psoriasis Research Center(Swepub:liu)chaen00 (author)
Linköpings universitetAvdelningen för neuro- och inflammationsvetenskap (creator_code:org_t)

In:Acta Dermato-Venereologica: Society for the Publication of Acta Dermato - Venereologica97:4, s. 441-4480001-55551651-2057

By the author/editor: Ekman, Anna-Kari ...; Vegfors, Jenny; Bivik, Cecilia, ...; Enerbäck, Charlo ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dermatology and ...

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