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Sublingual administration of atropine eyedrops in children with excessive drooling - a pilot study
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- Norderyd, Johanna (author)
- Jönköping University,HHJ. CHILD,National Oral Disability Centre for Rare Disorders, The Institute for Postgraduate Dental Education, Jönköping, Sweden,Institute Postgrad Dent Educ, Sweden; Jonköping University, Sweden
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- Graf, Jonas (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Department of Otorhinolaryngology and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
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- Marcusson, Agneta, 1956- (author)
- Linköpings universitet,Medicinska fakulteten,Avdelningen för Kirurgi, Ortopedi och Onkologi,Region Östergötland, Käkkliniken US,Department of Dentofacial Orthopedics, Maxillofacial Unit, Linköping University, Linköping, Sweden
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- Jönköping University HHJ CHILD (creator_code:org_t)
- 2015-12-27
- 2017
- English.
- In: International Journal of Paediatric Dentistry. - : WILEY-BLACKWELL. - 0960-7439 .- 1365-263X. ; 27:1, s. 22-29
- Journal article (peer-reviewed)
Abstract
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- BackgroundDrooling can be a severe disability and have high impact on daily life. Reversible treatment is preferable. AimTo analyse whether sublingual administration of atropine eyedrops is a useful reversible treatment option for severe drooling in children with disabilities. DesignThe study had a prospective, single-system research design. The participants served as their own controls. The study period was 3 weeks without treatment, 4 weeks with atropine eyedrop solution 10 mg/mL one drop a day followed by 4 weeks of one drop twice a day. Parents rating of their childs drooling was assessed on a 100-mm VAS, and unstimulated salivary secretion rate measurement was performed together with notations about side effects and practicality. ResultsParents VAS assessment of drooling decreased from a median (range) of 74 (40-98) at baseline to 48 (18-88) (P = 0.05) and 32 (12-85) (P = 0.004) after 4 weeks of atropine once a day and another 4 weeks of atropine twice a day, respectively (n = 11). Unstimulated salivary secretion rates decreased from baseline to end of study (P = 0.032). Several parents complained about difficult administration. No irreversible side effects were noted. ConclusionsSublingual atropine eyedrops may be an alternative for treatment of severe drooling in children with disabilities.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
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