Effects of estradiol, progesterone, and norethisterone on regional concentrations of galanin in the rat brain

Rugarn, Olof (author): Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet

Theodorsson, Annette (author): Linköpings universitet,Neurokirurgi,Hälsouniversitetet

Hammar, Mats (author): Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet

Theodorsson, Elvar (author): Linköpings universitet,Klinisk kemi,Hälsouniversitetet

(creator_code:org_t)

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

Concentrations of immunoreactive galanin were compared in eight gross brain regions of ovariectomized female rats treated with either estradiol, estradiol + progesterone, estradiol + norethisterone, or placebo. Higher concentrations with estradiol treatment compared with placebo were found in the pituitary (357%), frontal cortex (162%), occipital cortex (174%), hippocampus (170%), and median eminence (202%). A more profound difference with addition of progesterone or norethisterone was seen in the pituitary (529% and 467%, respectively). Sex steroids, particularly estradiol, modulate galanin concentrations not only in reproductive, but also in nonreproductive, brain regions.

By the author/editor: Rugarn, Olof; Theodorsson, Ann ...; Hammar, Mats; Theodorsson, Elv ...

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