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Probe for simultane...
Probe for simultaneous membrane and nucleus labeling in living cells and in vivo bioimaging using a two-photon absorption water-soluble Zn(II) terpyridine complex with a reduced pi-conjugation system
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- Tian, Xiaohe (author)
- Anhui University, Peoples R China
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- Zhang, Qian (author)
- Linköpings universitet,Ytors Fysik och Kemi,Tekniska fakulteten,Anhui University, Peoples R China
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- Zhang, Mingzhu (author)
- Anhui University, Peoples R China
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- Uvdal, Kajsa (author)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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- Wang, Qin (author)
- Anhui Agriculture University, Peoples R China
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- Chen, Junyang (author)
- Anhui University, Peoples R China
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- Du, Wei (author)
- Anhui University, Peoples R China
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- Huang, Bei (author)
- Anhui University, Peoples R China
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- Wu, Jieying (author)
- Anhui University, Peoples R China
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- Tian, Yupeng (author)
- Anhui University, Peoples R China; Nanjing University, Peoples R China
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(creator_code:org_t)
- 2017
- 2017
- English.
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In: Chemical Science. - : ROYAL SOC CHEMISTRY. - 2041-6520 .- 2041-6539. ; 8:1, s. 142-149
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https://liu.diva-por... (primary) (Raw object)
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https://pubs.rsc.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Small, biocompatible and water-soluble molecules with high two-photon absorption (2PA) cross-section values (delta) are in high demand for specific bioimaging applications. Here, two novel terpyridine derivative ligands with donor-acceptor (D-A) (L1) and donor-pi-acceptor (D-pi-A) (L2) models, and their corresponding Zn(II) complexes are designed and characterized. It was found that the two-photon absorption cross section values (d) in the near-infrared region (NIR, about 800 nm) are significantly enhanced for complexes 1 and 2 compared to their free D-A type ligand L1, while those of complexes 3 and 4 were greatly decreased relative to their free ligand L2, thus confirming that the smaller ligand (D-A type) displays a suitable Turn-ON fluorescence pair for two-photon fluorescence microscopy (2PFM). Firstly, the potential of simultaneously labeling a live cell plasma membrane and nucleus using complex 1 is demonstrated. In addition, live larval and adult zebrafish incubated with an optimal concentration of 1 demonstrated clear brain uptake. Lastly and importantly, using such a probe to visualize the blood-brain- barrier (BBB) capillary endothelial cells and penetrate the BBB into the central nervous system (CNS) intravenously in a mouse model is also explored.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Tian, Xiaohe
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Zhang, Qian
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Zhang, Mingzhu
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Uvdal, Kajsa
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Wang, Qin
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Chen, Junyang
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show more...
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Du, Wei
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Huang, Bei
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Wu, Jieying
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Tian, Yupeng
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Organic Chemistr ...
- Articles in the publication
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Chemical Science
- By the university
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Linköping University