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  • Gaillard, FrancoisParis Descartes University, France (author)

Use of computed tomography assessed kidney length to predict split renal GFR in living kidney donors

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2016-05-24
  • SPRINGER,2017
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-134596
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-134596URI
  • https://doi.org/10.1007/s00330-016-4410-7DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Screening of living kidney donors may require scintigraphy to split glomerular filtration rate (GFR). To determine the usefulness of computed tomography (CT) to split GFR, we compared scintigraphy-split GFR to CT-split GFR. We evaluated CT-split GFR as a screening test to detect scintigraphy-split GFR lower than 40 mL/min/1.73 m(2)/kidney. This was a monocentric retrospective study on 346 potential living donors who had GFR measurement, renal scintigraphy, and CT. We predicted GFR for each kidney by splitting GFR using the following formula: Volume-split GFR for a given kidney = measured GFR*[volume of this kidney/(volume of this kidney + volume of the opposite kidney)]. The same formula was used for length-split GFR. We compared length- and volume-split GFR to scintigraphy-split GFR at donation and with a 4-year follow-up. A better correlation was observed between length-split GFR and scintigraphy-split GFR (r = 0.92) than between volume-split GFR and scintigraphy-split GFR (r = 0.89). A length-split GFR threshold of 45 mL/min/1.73 m(2)/kidney had a sensitivity of 100 % and a specificity of 75 % to detect scintigraphy-split GFR less than 40 mL/min/1.73 m(2)/kidney. Both techniques with their respective thresholds detected living donors with similar eGFR evolution during follow-up. Length-split GFR can be used to detect patients requiring scintigraphy. aEuro cent Excellent correlation between kidney length and scintigraphy predicted GFR aEuro cent Kidney length screening detects all donors with GFR lower than 40 mL/min/1.73 m (2) aEuro cent Kidney length screening can replace scintigraphy screening.

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  • Pavlov, PatrikLinköpings universitet (author)
  • Tissier, Anne-MarieParis Descartes University, France (author)
  • Harache, BenoitParis Descartes University, France (author)
  • Eladari, DominiqueParis Descartes University, France; INSERM, France (author)
  • Timsit, Marc-OlivierParis Descartes University, France (author)
  • Fournier, CatherineParis Descartes University, France (author)
  • Leon, CarineParis Descartes University, France (author)
  • Hignette, ChantalParis Descartes University, France (author)
  • Friedlander, GerardParis Descartes University, France; INSERM, France (author)
  • Correas, Jean-MichelParis Descartes University, France (author)
  • Weinmann, PierreParis Descartes University, France (author)
  • Mejean, ArnaudParis Descartes University, France (author)
  • Houillier, PascalParis Descartes University, France; CNRS, France (author)
  • Legendre, ChristopheParis Descartes University, France (author)
  • Courbebaisse, MarieParis Descartes University, France; INSERM, France (author)
  • Linköpings universitetParis Descartes University, France (creator_code:org_t)

Related titles

  • In:European Radiology: SPRINGER27:2, s. 651-6590938-79941432-1084

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