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Potential Involveme...
Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis
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- Mattson, Lina (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Centre for Personalized Medicine
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- Lentini, Antonio (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten
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- Gawel, Danuta (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten
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- Badam, Tejaswi (author)
- Linköpings universitet,Bioinformatik,Tekniska fakulteten
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- Benson, Mikael (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Allergicentrum US
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- Ledin, Torbjörn (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Öron- näsa- och halskliniken US
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- Nestor, Colm (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten
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- Gustafsson, Mika (author)
- Linköpings universitet,Bioinformatik,Tekniska fakulteten
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- Serra I Musach, Jordi (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten
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- Björkander, Janne (author)
- County Council Jonköping, Sweden
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- Xiang, Zou (author)
- Hong Kong Polytech University, Peoples R China
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- Zhang, Huan (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten
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(creator_code:org_t)
- HINDAWI PUBLISHING CORP, 2016
- 2016
- English.
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In: Journal of Immunology Research. - : HINDAWI PUBLISHING CORP. - 2314-8861 .- 2314-7156.
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Abstract
Subject headings
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- Specific immunotherapy (SIT) reverses the symptoms of seasonal allergic rhinitis (SAR) in most patients. Recent studies report type I interferons shifting the balance between type I T helper cell (Th1) and type II T helper cells (Th2) towards Th2 dominance by inhibiting the differentiation of naive Tcells into Th1 cells. As SIT is thought to cause a shift towardsTh1 dominance, we hypothesized that SIT would alter interferon type I signaling. To test this, allergen and diluent challenged CD4(+) T cells from healthy controls and patients from different time points were analyzed. The initial experiments focused on signature genes of the pathway and found complex changes following immunotherapy, which were consistent with our hypothesis. As interferon signaling involves multiple genes, expression profiling studies were performed, showing altered expression of the pathway. These findings require validation in a larger group of patients in further studies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Mattson, Lina
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Lentini, Antonio
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Gawel, Danuta
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Badam, Tejaswi
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Benson, Mikael
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Ledin, Torbjörn
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show more...
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Nestor, Colm
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Gustafsson, Mika
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Serra I Musach, ...
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Björkander, Jann ...
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Xiang, Zou
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Zhang, Huan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
- Articles in the publication
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Journal of Immun ...
- By the university
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Linköping University