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Solid-phase synthes...
Solid-phase synthesis of libraries generated from a 4-phenyl-2-carboxy-piperazine Scaffold
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- Nilsson, Jonas W. (author)
- Linköpings universitet,Organisk Kemi,Tekniska högskolan
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- Thorstensson, Fredrik (author)
- Linköpings universitet,Organisk Kemi,Tekniska högskolan
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- Kvarnström, Ingemar (author)
- Linköpings universitet,Organisk Kemi,Tekniska högskolan
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- Oprea, Tudor (author)
- Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Stockholm, Sweden
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- Samuelsson, Bertil (author)
- Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Stockholm, Sweden
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Nilsson, Ingemar (author)
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(creator_code:org_t)
- 2001-09-06
- 2001
- English.
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In: Journal of Combinatorial Chemistry. - : American Chemical Society (ACS). - 2156-8952 .- 1520-4766 .- 1520-4774. ; 3:6, s. 546-553
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Abstract
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- Strategies for finding novel structures of therapeutical interest are discussed. The rationale for the selection of the two scaffolds N4-(m-aminophenyl)-piperazine-2-carboxylic acid E and N4-(o-aminophenyl)-piperazine-2-carboxylic F is described. The synthesis of the appropriate precursors to scaffold E and F and their use in solid-phase chemistry are described. A 160-member library was produced combining these novel piperazine scaffolds with eight sulfonyl chlorides/acid chlorides and 10 amines. The compound library prepared was analyzed using LC-MS, showing the expected base peak in all wells at an average purity of 82%.
Keyword
- NATURAL SCIENCES
- NATURVETENSKAP
Publication and Content Type
- ref (subject category)
- art (subject category)
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