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L-dopa pharmacokine...
L-dopa pharmacokinetics studied with microdialysis in patients with Parkinson's disease and a history of malignant melanoma
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- Dizdar (Dizdar Segrell), Nil (author)
- Linköpings universitet,Neurologi,Hälsouniversitetet
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- Granerus, Ann-Kathrine (author)
- Linköpings universitet,Geriatrik,Hälsouniversitetet
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- Hannestad, Ulf (author)
- Linköpings universitet,Klinisk kemi,Hälsouniversitetet
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- Kullman, Anita (author)
- Linköpings universitet,Klinisk kemi,Hälsouniversitetet
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- Ljungdahl, Å. (author)
- Department of Neurology, Huddinge Hospital, Stockholm
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- Olsson, Jan-Edvin (author)
- Östergötlands Läns Landsting,Linköpings universitet,Neurologi,Hälsouniversitetet,Neurologiska kliniken
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- Kågedal, Bertil (author)
- Östergötlands Läns Landsting,Linköpings universitet,Klinisk kemi,Hälsouniversitetet
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(creator_code:org_t)
- 2009-01-29
- 1999
- English.
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In: Acta neurologica Scandinavica. - : Hindawi Limited. - 0001-6314 .- 1600-0404. ; 100:4, s. 231-237
- Related links:
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http://urn.kb.se/res...
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Abstract
Subject headings
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- OBJECTIVES: The pharmacokinetics of free L-dopa in blood and tissue of five parkinsonian patients with malignant melanoma was studied with microdialysis. In one case the effect of L-dopa treatment on 5-S-cysteinyldopa and the melanoma was studied. Gastric emptying and its effects on free L-dopa in blood were also investigated in one of the patients.METHODS: Five patients were given 100 mg L-dopa with 25 mg benserazide. Blood and dialysates from the circulation and fatty tissue were collected for analysis. [13C]-Octanoic breath test was used for analyzing gastric half-emptying time.RESULTS: Four of the patients had similar pharmacokinetic patterns for L-dopa and a significant (P < 0.05) increase of serum 5-S-cysteinyldopa occurring 30 min after L-dopa intake. Delayed L-dopa peaks and slow gastric half-emptying time were found in 1 patient. A dose-dependent increase of 5-S-cysteinyldopa occurred but no melanoma metastases were seen during long-term L-dopa therapy.CONCLUSION: L-dopa therapy increases 5-S-cysteinyldopa levels but does not seem to cause progress of melanomas. Gastric emptying impacts L-dopa pharmacokinetics.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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