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  • Ajileye, AdebisiBirmingham Heartlands Hospital, England (author)

Some Synonymous and Nonsynonymous gyrA Mutations in Mycobacterium tuberculosis Lead to Systematic False-Positive Fluoroquinolone Resistance Results with the Hain GenoType MTBDRsl Assays

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • AMER SOC MICROBIOLOGY,2017
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-136869
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-136869URI
  • https://doi.org/10.1128/AAC.02169-16DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Swedish Heart and Lung Foundation; Marianne and Marcus Wallenberg Foundation; Wellcome Trust [201344/Z/16/Z]; NIHR Oxford Biomedical Research Centre; NIHR Oxford Health Protection Research Unit on Healthcare Associated Infection and Antimicrobial Resistance [HPRU-2012-10041]; Health Innovation Challenge Fund [T5-358, HICF-T5-342, WT098600]; German Center for Infection Research (DZIF); European Union TB-PAN-NET [FP7-223681]; PathoNgenTrace [278864]; UK Department of Health; Pacific Biosciences, Inc.; Illumina, Inc.; Colciencias; Hain Lifescience
  • In this study, using the Hain GenoType MTBDRsl assays (versions 1 and 2), we found that some nonsynonymous and synonymous mutations in gyrA in Mycobacterium tuberculosis result in systematic false-resistance results to fluoroquinolones by preventing the binding of wild-type probes. Moreover, such mutations can prevent the binding of mutant probes designed for the identification of specific resistance mutations. Although these mutations are likely rare globally, they occur in approximately 7% of multidrug-resistant tuberculosis strains in some settings.

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  • Alvarez, NatalyCorp Invest Biol, Colombia; University of Pontificia Bolivariana, Colombia (author)
  • Merker, MatthiasResearch Centre Borstel, Germany; German Centre Infect Research, Germany (author)
  • Walker, Timothy M.University of Oxford, England (author)
  • Akter, SuriyaInstitute Trop Med, Belgium (author)
  • Brown, KerstinBirmingham Heartlands Hospital, England (author)
  • Moradigaravand, DaneshWellcome Trust Sanger Institute, England (author)
  • Schön, ThomasLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Kalmar County Hospital, Sweden(Swepub:liu)thosc49 (author)
  • Andres, SoenkeResearch Centre Borstel, Germany (author)
  • Schleusener, ViolaResearch Centre Borstel, Germany (author)
  • Omar, Shaheed V.Centre TB, South Africa (author)
  • Coll, FrancescLondon School Hyg and Trop Med, England (author)
  • Huang, HairongCapital Medical University, Peoples R China (author)
  • Diel, RolandUniversity Hospital, Germany (author)
  • Ismail, NazirCentre TB, South Africa (author)
  • Parkhill, JulianWellcome Trust Sanger Institute, Hinxton, United Kingdom (author)
  • de Jong, Bouke C.Institute Trop Med, Belgium (author)
  • Peto, Tim E. A.University of Oxford, England (author)
  • Crook, Derrick W.University of Oxford, England; Public Health England Microbiol Serv, England (author)
  • Niemann, StefanResearch Centre Borstel, Germany; German Centre Infect Research, Germany (author)
  • Robledo, JaimeCorp Invest Biol, Colombia; University of Pontificia Bolivariana, Colombia (author)
  • Grace Smith, E.Birmingham Heartlands Hospital, England (author)
  • Peacock, Sharon J.Wellcome Trust Sanger Institute, England; London School Hyg and Trop Med, England; University of Cambridge, England (author)
  • Koeser, Claudio U.University of Cambridge, England (author)
  • Birmingham Heartlands Hospital, EnglandCorp Invest Biol, Colombia; University of Pontificia Bolivariana, Colombia (creator_code:org_t)

Related titles

  • In:Antimicrobial Agents and Chemotherapy: AMER SOC MICROBIOLOGY61:40066-48041098-6596

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