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Enantioselective An...
Enantioselective Analysis of Citalopram and Metabolites in Adolescents
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- Carlsson, Björn (author)
- Östergötlands Läns Landsting,Linköpings universitet,Klinisk farmakologi,Hälsouniversitetet
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- Olsson, Gunilla (author)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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- Reis, Margareta (author)
- Linköpings universitet,Psykiatri,Hälsouniversitetet
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- Wålinder, Jan (author)
- Östergötlands Läns Landsting,Linköpings universitet,Psykiatri,Hälsouniversitetet,Psykiatriska kliniken
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- Nordin, Conny (author)
- Östergötlands Läns Landsting,Linköpings universitet,Psykiatri,Hälsouniversitetet,Psykiatriska kliniken
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- Lundmark, Jöns (author)
- Östergötlands Läns Landsting,Linköpings universitet,Geriatrik,Hälsouniversitetet,Geriatriska kliniken
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- Scordo, Gabriella (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Pharmacogenetics
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- Dahl, Marja-Liisa (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för medicinska vetenskaper,Pharmacogenetics
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- Bengtsson, Finn (author)
- Östergötlands Läns Landsting,Linköpings universitet,Klinisk farmakologi,Hälsouniversitetet
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- Ahlner, Johan (author)
- Linköpings universitet,Klinisk farmakologi,Hälsouniversitetet
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2001
- 2001
- English.
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In: Therapeutic drug monitoring. - : Ovid Technologies (Wolters Kluwer Health). - 0163-4356. ; 23, s. 658-
- Related links:
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http://www.ncbi.nlm....
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http://urn.kb.se/res...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Studies of the antidepressant effect and pharmacokinetics of citalopram have been performed in adults, but the effects on children and adolescents have only been studied to a minor extent despite its increasing use in these age groups. The aim of this study was to investigate a group of adolescents treated for depression, with respect to the steady-state plasma concentrations of the enantiomers of citalopram and its demethylated metabolites desmethylcitalopram and didesmethylcitalopram. Moreover, the authors studied the genotypes for the polymorphic cytochrome P450 enzymes CYP2D6 and CYP2C19 in relation to the different enantiomers. The S/R ratios of citalopram and desmethylcitalopram found in this study of 19 adolescents were similar to studies involving older patients. The concentrations of the R-(-)- and S-(+)-enantiomers of citalopram and desmethylcitalopram were also in agreement with values from earlier studies, the R-(-)-enantiomer (distomer) being the major enantiomer. The results indicate that the use of oral contraceptives may have some influence on the metabolism of citalopram. This might be because of an interaction of the contraceptive hormones with the CYP2C19 enzyme.
Keyword
- Citalopram; Enantiomer; Genotypes; Adolescent
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Carlsson, Björn
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Olsson, Gunilla
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Reis, Margareta
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Wålinder, Jan
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Nordin, Conny
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Lundmark, Jöns
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Scordo, Gabriell ...
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Dahl, Marja-Liis ...
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Bengtsson, Finn
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Ahlner, Johan
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- Articles in the publication
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Therapeutic drug ...
- Ther Drug Monit
- By the university
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Linköping University
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Uppsala University
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Karolinska Institutet