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Two-Photon Active O...
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Wang, HuiAnhui University, Peoples R China
(author)
Two-Photon Active Organotin(IV) Carboxylate Complexes for Visualization of Anticancer Action
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2017-04-03
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AMER CHEMICAL SOC,2017
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Numbers
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LIBRIS-ID:oai:DiVA.org:liu-138267
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-138267URI
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https://doi.org/10.1021/acsbiomaterials.6b00786DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|National Natural Science Foundation of China [21602003, 51372003, 51672003, 51432001, 21501001, 51472002]; Ministry of Education; Higher Education Revitalization Plan Talent Project
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It is still a challenge that organotin(IV) carboxylate complexes with high-performance two-photon activity for cancer therapy. At present work, two novel organotin carboxylate complexes LSn1 and LSn2, containing coumarin moiety, were rationally designed for two-photon fluorescent imaging and anticancer purpose. The complexes possessed large two-photon action cross-sections and high quantum yields. Living cells evaluation revealed that complexes LSn1 and LSn2 exhibited good biocompatibility and deep tissue penetration over femtosecond laser with wavelength of 840 nm. Furthermore, the antitumor active and as well as possible mechanism of complexes LSn1 and LSn2 have been investigated systematically. The results indicated that complexes LSn1 and LSn2 could induce apoptotic cell death through a mitochondria] dysfunction and ROS elevation pathway. The present work provides a strategy for rationally designing organotin(IV) carboxylate complexes with two-photon activity and antitumor activity.
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Hu, LeiAnhui University, Peoples R China
(author)
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Du, WeiAnhui University, Peoples R China
(author)
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Tian, XiaoheAnhui University, Peoples R China
(author)
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Zhang, QiongAnhui University, Peoples R China
(author)
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Hu, Zhang-JunLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten(Swepub:liu)zhahu14
(author)
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Luo, LeiSouthwest University, Peoples R China
(author)
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Zhou, HongpingAnhui University, Peoples R China
(author)
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Wu, JieyingAnhui University, Peoples R China
(author)
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Tian, YupengAnhui University, Peoples R China; Nanjing University, Peoples R China
(author)
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Anhui University, Peoples R ChinaMolekylär ytfysik och nanovetenskap
(creator_code:org_t)
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In:ACS Biomaterials Science & Engineering: AMER CHEMICAL SOC3:5, s. 836-8422373-9878
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Wang, Hui
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Hu, Lei
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Du, Wei
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Tian, Xiaohe
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Zhang, Qiong
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Hu, Zhang-Jun
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Luo, Lei
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Zhou, Hongping
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Wu, Jieying
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Tian, Yupeng
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Linköping University