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Feeding-related imm...
Feeding-related immune responsive brain stem neurons : association with CGRP
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- Paues, Jakob (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Engblom, David (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Mackerlova, Ludmila (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Ericsson-Dahlstrand, Anders (author)
- Department of Medicine, Unit of Rheumatology, The Karolinska Institute, Stockholm, Sweden
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- Blomqvist, Anders (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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(creator_code:org_t)
- 2001
- 2001
- English.
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In: Neuroreport. - 0959-4965 .- 1473-558X. ; 12:11, s. 2399-2403
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http://www.neurorepo...
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http://urn.kb.se/res...
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Abstract
Subject headings
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- Using dual-labeling in situ hybridization histochemistry, the neurotransmitter expression of immune-responsive neurons in the pontine parabrachial nucleus, a major relay for interoceptive information, was investigated. Intravenous injection of bacterial wall lipopolysaccharide resulted in dense c-fos mRNA expression in the external lateral parabrachial nucleus, and a majority of the c-fos expressing cells also expressed calcitonin gene-related peptide (CGRP) mRNA. In contrast CGRP-posi- tive cells in the adjoining external medial subnucleus were c-fos negative. Taken together with previous hodological and behavioral studies, these data suggest that CGRPergic parabrachial neurons may mediate lipopolysaccharide-induced anorexia by means of their projection to central nucleus of the amygdala.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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