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Annexin A1 regulate...
Annexin A1 regulates intestinal mucosal injury, inflammation, and repair
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- Babbin, Brian A. (författare)
- Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Atlanta, GA, USA
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- Laukoetter, Mike G. (författare)
- Department of General Surgery, University of Muenster, Muenster, Germany
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- Nava, Porfirio (författare)
- Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Atlanta, GA, USA
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- Koch, Stefan (författare)
- Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Atlanta, GA, USA
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- Lee, Winston Y. (författare)
- Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Atlanta, GA, USA
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- Capaldo, Christopher T. (författare)
- Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Atlanta, GA, USA
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- Peatman, Eric (författare)
- Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Atlanta, GA, USA
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- Severson, Eric A. (författare)
- Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Atlanta, GA, USA
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- Flower, Roderick J. (författare)
- The William Harvey Research Institute, Barts and The London School of Medicine, London, United Kingdom
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- Perretti, Mauro (författare)
- The William Harvey Research Institute, Barts and The London School of Medicine, London, United Kingdom
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- Parkos, Charles A. (författare)
- Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Atlanta, GA, USA
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- Nusrat, Asma (författare)
- Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Atlanta, GA, USA
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(creator_code:org_t)
- Bethesda, United States : American Association of Immunologists, 2008
- 2008
- Engelska.
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Ingår i: Journal of Immunology. - Bethesda, United States : American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 181:7, s. 5035-5044
- Relaterad länk:
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http://www.jimmunol....
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https://urn.kb.se/re...
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https://doi.org/10.4...
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Abstract
Ämnesord
Stäng
- During mucosal inflammation, a complex array of proinflammatory and protective mechanisms regulates inflammation and severity of injury. Secretion of anti-inflammatory mediators is a mechanism that is critical in controlling inflammatory responses and promoting epithelial restitution and barrier recovery. AnxA1 is a potent anti-inflammatory protein that has been implicated to play a critical immune regulatory role in models of inflammation. Although AnxA1 has been shown to be secreted in intestinal mucosal tissues during inflammation, its potential role in modulating the injury/inflammatory response is not understood. In this study, we demonstrate that AnxA1-deficient animals exhibit increased susceptibility to dextran sulfate sodium (DSS)-induced colitis with greater clinical morbidity and histopathologic mucosal injury. Furthermore, impaired recovery following withdrawal of DSS administration was observed in AnxA1 (-/-) animals compared with wild-type (WT) control mice that was independent of inflammatory cell infiltration. Since AnxA1 exerts its anti-inflammatory properties through stimulation of ALX/FPRL-1, we explored the role of this receptor-ligand interaction in regulating DSS-induced colitis. Interestingly, treatment with an ALX/FPRL-1 agonist, 15-epi-lipoxin A4 reversed the enhanced sensitivity of AnxA1 (-/-) mice to DSS colitis. In contrast, 15-epi-lipoxin A4 did not significantly improve the severity of disease in WT animals. Additionally, differential expression of ALX/FPLR-1 in control and DSS-treated WT and AnxA1-deficient animals suggested a potential role for AnxA1 in regulating ALX/FPRL-1 expression under pathophysiological conditions. Together, these results support a role of endogenous AnxA1 in the protective and reparative properties of the intestinal mucosal epithelium.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Animals
- Annexin A1/biosynthesis/deficiency/genetics/*physiology
- Colitis/chemically induced/metabolism/pathology
- Dextran Sulfate/toxicity
- Female
- Genetic Predisposition to Disease
- Inflammation Mediators/metabolism/*physiology
- Intestinal Mucosa/drug effects/*metabolism/*pathology
- Mice
- Mice
- Inbred BALB C
- Mice
- Knockout
- Severity of Illness Index
- Wound Healing/drug effects/*immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Babbin, Brian A.
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Laukoetter, Mike ...
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Nava, Porfirio
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Koch, Stefan
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Lee, Winston Y.
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Capaldo, Christo ...
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visa fler...
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Peatman, Eric
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Severson, Eric A ...
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Flower, Roderick ...
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Perretti, Mauro
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Parkos, Charles ...
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Nusrat, Asma
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Cell och molekyl ...
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Journal of Immun ...
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