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Neural inhibition c...
Neural inhibition can explain negative BOLD responses : A mechanistic modelling and fMRI study
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- Sten, Sebastian (author)
- Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV
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- Lundengård, Karin (author)
- Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV
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- Witt, Suzanne Tyson, 1979- (author)
- Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinska fakulteten
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- Cedersund, Gunnar (author)
- Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten
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- Elinder, Fredrik (author)
- Linköpings universitet,Avdelning för neurobiologi,Medicinska fakulteten
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- Engström, Maria (author)
- Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV
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(creator_code:org_t)
- Elsevier, 2017
- 2017
- English.
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In: NeuroImage. - : Elsevier. - 1053-8119 .- 1095-9572. ; 158, s. 219-231
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Functional magnetic resonance imaging (fMRI) of hemodynamic changes captured in the blood oxygen level-dependent (BOLD) response contains information of brain activity. The BOLD response is the result of a complex neurovascular coupling and comes in at least two fundamentally different forms: a positive and a negative deflection. Because of the complexity of the signaling, mathematical modelling can provide vital help in the data analysis. For the positive BOLD response, there are plenty of mathematical models, both physiological and phenomenological. However, for the negative BOLD response, no physiologically based model exists. Here, we expand our previously developed physiological model with the most prominent mechanistic hypothesis for the negative BOLD response: the neural inhibition hypothesis. The model was trained and tested on experimental data containing both negative and positive BOLD responses from two studies: 1) a visual-motor task and 2) a workin-gmemory task in conjunction with administration of the tranquilizer diazepam. Our model was able to predict independent validation data not used for training and provides a mechanistic underpinning for previously observed effects of diazepam. The new model moves our understanding of the negative BOLD response from qualitative reasoning to a quantitative systems-biology level, which can be useful both in basic research and in clinical use.
Subject headings
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
Keyword
- fMRI; Neurovascular coupling; GABA; glutamate; Cerebral blood flow; Blood oxygen level dependent response; Hemodynamic response; Systems biology
Publication and Content Type
- ref (subject category)
- art (subject category)
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