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Label-free detectio...
Label-free detection of interleukin-6 using electrolyte gated organic field effect transistors
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- Diacci, Chiara (author)
- Linköpings universitet,Fysik och elektroteknik,Tekniska fakulteten,University of Modena and Reggio Emilia, Italy
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- Berto, Marcello (author)
- University of Modena and Reggio Emilia, Italy; University of Ferrara, Italy
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- Di Lauro, Michele (author)
- University of Modena and Reggio Emilia, Italy
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- Bianchini, Elena (author)
- University of Modena and Reggio Emilia, Italy
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- Pinti, Marcello (author)
- University of Modena and Reggio Emilia, Italy
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- Simon, Daniel (author)
- Linköpings universitet,Fysik och elektroteknik,Tekniska fakulteten
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- Biscarini, Fabio (author)
- University of Modena and Reggio Emilia, Italy
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- Bortolotti, Carlo A. (author)
- University of Modena and Reggio Emilia, Italy
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(creator_code:org_t)
- AMER INST PHYSICS, 2017
- 2017
- English.
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In: Biointerphases. - : AMER INST PHYSICS. - 1934-8630 .- 1559-4106. ; 12:5
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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http://liu.diva-port...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Cytokines are small proteins that play fundamental roles in inflammatory processes in the human body. In particular, interleukin (IL)-6 is a multifunctional cytokine, whose increased levels are associated with infection, cancer, and inflammation. The quantification of IL-6 is therefore of primary importance in early stages of inflammation and in chronic diseases, but standard techniques are expensive, time-consuming, and usually rely on fluorescent or radioactive labels. Organic electronic devices and, in particular, organic field-effect transistors (OFETs) have been proposed in the recent years as novel platforms for label-free protein detection, exploiting as sensing unit surface-immobilized antibodies or aptamers. Here, the authors report two electrolyte-gated OFETs biosensors for IL-6 detection, featuring monoclonal antibodies and peptide aptamers adsorbed at the gate. Both strategies yield biosensors that can work on a wide range of IL-6 concentrations and exhibit a remarkable limit of detection of 1 pM. Eventually, electrolyte gated OFETs responses have been used to extract and compare the binding thermodynamics between the sensing moiety, immobilized at the gate electrode, and IL-6. (C) 2017 American Vacuum Society.
Subject headings
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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