Search: onr:"swepub:oai:DiVA.org:liu-141934" > beta-Configured cli...
Fältnamn | Indikatorer | Metadata |
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000 | 04023naa a2200469 4500 | |
001 | oai:DiVA.org:liu-141934 | |
003 | SwePub | |
008 | 171013s2017 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-336822 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1419342 URI |
024 | 7 | a https://doi.org/10.1039/c7nj00716g2 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3368222 URI |
040 | a (SwePub)liud (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Elgland, Mathias,d 1987-u Linköpings universitet,Kemi,Tekniska fakulteten,Linkopings Univ, IFM Dept Biol Chem & Phys, S-58183 Linkoping, Sweden.4 aut0 (Swepub:liu)matel79 |
245 | 1 0 | a beta-Configured clickable [F-18] FDGs as novel F-18-fluoroglycosylation tools for PET |
264 | c 2017 | |
264 | 1 | b ROYAL SOC CHEMISTRY,c 2017 |
338 | a electronic2 rdacarrier | |
500 | a Funding Agencies|Swedish Foundation for Strategic Research; Swedish Research Council | |
520 | a In oncology and neurology the F-18-radiolabeled glucose analogue 2-deoxy-2-[F-18]fluoro-D-glucose ([F-18]FDG) is by far the most commonly employed metabolic imaging agent for positron emission tomography (PET). Herein, we report a novel synthetic route to beta-configured mannopyranoside precursors and a chemoselective F-18-fluoroglycosylation method that employ two b-configured [F-18]FDG derivatives equipped with either a terminal azide or alkyne aglycon respectively, for use as a CuAAC clickable tool set for PET. The b-configured precursors provided the corresponding [F-18]FDGs in a radiochemical yield of 77-88%. Further, the clickability of these [F-18]FDGs was investigated by click coupling to the suitably functionalized Fmoc-protected amino acids, Fmoc-N-(propargyl)-glycine and Fmoc-3-azido-L-alanine, which provided the F-18-fluoroglycosylated amino acid conjugates in radiochemical yields of 75-83%. The F-18-fluoroglycosylated amino acids presented herein constitute a new and interesting class of metabolic PET radiotracers. | |
650 | 7 | a NATURVETENSKAPx Kemix Organisk kemi0 (SwePub)104052 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciencesx Organic Chemistry0 (SwePub)104052 hsv//eng |
650 | 7 | a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng |
700 | 1 | a Nordeman, Patriku Uppsala universitet,Avdelningen för organisk farmaceutisk kemi,Uppsala University, Sweden4 aut0 (Swepub:uu)patno435 |
700 | 1 | a Fyrner, Timmy,d 1981-u Linköpings universitet,Kemi,Tekniska fakulteten,Linkopings Univ, IFM Dept Biol Chem & Phys, S-58183 Linkoping, Sweden.4 aut0 (Swepub:liu)timfy80 |
700 | 1 | a Antoni, Gunnaru Uppsala universitet,Avdelningen för Molekylär Avbildning,Uppsala University, Sweden4 aut0 (Swepub:uu)gunnarat |
700 | 1 | a Nilsson, Peter,d 1970-u Linköpings universitet,Kemi,Tekniska fakulteten,Linkopings Univ, IFM Dept Biol Chem & Phys, S-58183 Linkoping, Sweden.4 aut0 (Swepub:liu)petni61 |
700 | 1 | a Konradsson, Peter,d 1957-u Linköpings universitet,Kemi,Tekniska fakulteten,Linkopings Univ, IFM Dept Biol Chem & Phys, S-58183 Linkoping, Sweden.4 aut0 (Swepub:liu)petko14 |
710 | 2 | a Linköpings universitetb Kemi4 org |
773 | 0 | t New Journal of Chemistryd : ROYAL SOC CHEMISTRYg 41:18, s. 10231-10236q 41:18<10231-10236x 1144-0546x 1369-9261 |
856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1149178/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://liu.diva-portal.org/smash/get/diva2:1149178/FULLTEXT01 |
856 | 4 | u https://doi.org/10.1039/c7nj00716gy Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1168204/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-141934 |
856 | 4 8 | u https://doi.org/10.1039/c7nj00716g |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-336822 |
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