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Involvement of inte...
Involvement of interleukin-1 type 1 receptors in lipopolysaccharide-induced sickness responses
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- Matsuwaki, Takashi, 1978- (author)
- Linköpings universitet,Avdelning för neurobiologi,Medicinska fakulteten,University of Tokyo, Japan
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- Shionoya, Kiseko, 1964- (author)
- Linköpings universitet,Avdelning för neurobiologi,Medicinska fakulteten
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- Ihnatko, Robert, PhD, 1972- (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Eskilsson, Anna, 1986- (author)
- Linköpings universitet,Avdelning för neurobiologi,Medicinska fakulteten
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- Kakuta, Shigeru (author)
- University of Tokyo, Japan
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- Dufour, Sylvie (author)
- CNRS, France
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- Schwaninger, Markus (author)
- University of Lubeck, Germany
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- Waisman, Ari (author)
- Johannes Gutenberg University of Mainz, Germany
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- Mueller, Werner (author)
- University of Manchester, England
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- Pinteaux, Emmanuel (author)
- University of Manchester, England
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- Engblom, David, 1975- (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten
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- Blomqvist, Anders, 1949- (author)
- Linköpings universitet,Avdelning för neurobiologi,Medicinska fakulteten
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(creator_code:org_t)
- Elsevier, 2017
- 2017
- English.
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In: Brain, behavior, and immunity. - : Elsevier. - 0889-1591 .- 1090-2139. ; 66, s. 165-176
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Abstract
Subject headings
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- Sickness responses to lipopolysaccharide (LPS) were examined in mice with deletion of the interleukin (IL)-1 type 1 receptor (IL-1R1). IL-1R1 knockout (1(0) mice displayed intact anorexia and HPA-axis activation to intraperitoneally injected LPS (anorexia: 10 or 120 mu g/kg; HPA-axis: 120 mu g/kg), but showed attenuated but not extinguished fever (120 g/kg). Brain PGE2 synthesis was attenuated, but Cox-2 induction remained intact. Neither the tumor necrosis factor-alpha (TNF alpha) inhibitor etanercept nor the IL -6 receptor antibody tocilizumab abolished the LPS induced fever in IL -1R1 KO mice. Deletion of IL -1R1 specifically in brain endothelial cells attenuated the LPS induced fever, but only during the late, 3rd phase of fever, whereas deletion of IL-1R1 on neural cells or on peripheral nerves had little or no effect on the febrile response. We conclude that while IL-1 signaling is not critical for LPS induced anorexia or stress hormone release, IL-1R1, expressed on brain endothelial cells, contributes to the febrile response to LPS. However, also in the absence of IL-1R1, LPS evokes a febrile response, although this is attenuated. This remaining fever seems not to be mediated by IL-6 receptors or TNFa, but by some yet unidentified pyrogenic factor.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Interleukin-1 type 1 receptor; Lipopolysaccharide; Fever; Anorexia; ACTH; Corticosterone; Endothelial cells; THF alpha; Interleukin-6; PGE(2)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Matsuwaki, Takas ...
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Shionoya, Kiseko ...
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Ihnatko, Robert, ...
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Eskilsson, Anna, ...
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Kakuta, Shigeru
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Dufour, Sylvie
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Schwaninger, Mar ...
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Waisman, Ari
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Mueller, Werner
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Pinteaux, Emmanu ...
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Engblom, David, ...
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Blomqvist, Ander ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Brain, behavior, ...
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Linköping University