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Expression of low-d...
Expression of low-density lipoprotein-related receptors 5 and 6 (LRP5/6) in psoriasis skin
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- Duvetorp, Albert (author)
- Regional Jönköping County, Sweden
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- Slind Olsen, Renate (author)
- Karolinska Institutet,Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Regional Jonköping County, Sweden
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- Nyström, Helena (author)
- Regional Jonköping County, Sweden
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- Skarstedt, Marita (author)
- Regional Jonköping County, Sweden
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- Dienus, Olaf (author)
- Regional Jonköping County, Sweden
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- Mrowietz, Ulrich (author)
- University of Medical Centre Schleswig Holstein, Germany
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- Soederman, Jan (author)
- Regional Jonköping County, Sweden
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- Seifert, Oliver (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Regional Jonköping County, Sweden
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(creator_code:org_t)
- 2017-07-09
- 2017
- English.
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In: Experimental dermatology. - : WILEY. - 0906-6705 .- 1600-0625. ; 26:11, s. 1033-1038
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Low-density lipoprotein-related receptors 5 and 6 (LRP5/6) are transmembrane receptors with key functions in canonical Wnt signalling. Wnt ligands are thought to play an important role in innate immunity and psoriasis, and recent studies assigned LRP5/6 anti-inflammatory properties. The objective of this study was to investigate the expression of LRP5 and LRP6 in lesional and non-lesional skin in peripheral blood and in mononuclear cells of patients with chronic plaque type psoriasis compared with control individuals. To investigate the effect of UV-B radiation, LRP5/6 skin gene expression was analysed before and after narrowband UV-B treatment. Our results showed significantly decreased gene expression of LRP5 and LRP6 in lesional skin and in peripheral blood from patients with psoriasis compared with non-lesional skin and healthy control skin. Immunohistochemistry did not reveal differences in protein expression of LRP5/6. Narrowband UV-B treatment induced a significant increase in LRP5 and LRP6 gene expression in lesional skin. Decreased gene expression of LRP5/6 in lesional skin and upregulation after nb UV-B treatment suggest a possible role for LRP5/6 in psoriasis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Keyword
- LRP5/6 gene expression; UV-B treatment; Wnt/beta-catenin signalling
Publication and Content Type
- ref (subject category)
- art (subject category)
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