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Pediatric norovirus...
Pediatric norovirus GII.4 infections in Nicaragua, 1999-2015
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- Bucardo, Filemon (författare)
- National Autonomous University of Nicaragua, Nicaragua
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- Reyes, Yaoska (författare)
- National Autonomous University of Nicaragua, Nicaragua
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- Becker-Dreps, Sylvia (författare)
- University of N Carolina, NC USA
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- Bowman, Natalie (författare)
- University of N Carolina, NC USA
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- Gruber, Joann F. (författare)
- University of N Carolina, NC USA
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- Vinje, Jan (författare)
- National Centre Immunizat and Resp Disease, GA USA
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- Espinoza, Felix (författare)
- National Autonomous University of Nicaragua, Nicaragua
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- Paniagua, Margarita (författare)
- National Autonomous University of Nicaragua, Nicaragua
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- Balmaseda, Angel (författare)
- Minist Heatlh, Nicaragua
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- Svensson, Lennart (författare)
- Karolinska Institutet,Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Nordgren, Johan (författare)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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(creator_code:org_t)
- ELSEVIER SCIENCE BV, 2017
- 2017
- Engelska.
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Ingår i: Infection, Genetics and Evolution. - : ELSEVIER SCIENCE BV. - 1567-1348 .- 1567-7257. ; 55, s. 305-312
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objectives: Investigate clinical and epidemiological factors of pediatric GII.4 norovirus infections in children with acute gastroenteritis (AGE) in Nicaragua between 1999 and 2015. Methods: We retrospectively analyzed laboratory and epidemiologic data from 1,790 children amp;lt;= 7 years with AGE from 6 hospitals in Nicaragua (n = 538), and 3 community clinics (n = 919) and households (n = 333) in Leon, between 1999 and 2015. Moreover, asymptomatic children from community clinics (n = 162) and households (n = 105) were enrolled. Norovirus was detected by real-time PCR and genotyped by sequencing the N-terminal and shell region of the capsid gene. Results: Norovirus was found in 19% (n = 338) and 12% (n = 32) of children with and without AGE, respectively. In total, 20 genotypes including a tentatively new genotype were detected. Among children with AGE, the most common genotypes were GII.4 (53%), GII.14 (7%), GII.3 (6%) and GI.3 (6%). In contrast, only one (1.4%) GII.4 was found in asymptomatic children. The prevalence of GII.4 infections was significantly higher in children between 7 and 12 months of age. The prevalence of GII.4 was lowest in households (38%), followed by community clinics (50%) and hospitals (75%). Several different GII.4 variants were detected and their emergence followed the global temporal trend. Conclusions: Overall our study found the predominance of pediatric GII.4 norovirus infections in Nicaragua mostly occurring in children between 7 and 12 months of age, implicating GII.4 as the main norovirus vaccine target.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Norovirus; Nicaragua; GII.4; Pediatric; Gastroenteritis; Asymptomatic; Community
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Bucardo, Filemon
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Reyes, Yaoska
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Becker-Dreps, Sy ...
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Bowman, Natalie
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Gruber, Joann F.
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Vinje, Jan
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visa fler...
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Espinoza, Felix
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Paniagua, Margar ...
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Balmaseda, Angel
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Svensson, Lennar ...
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Nordgren, Johan
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
- Artiklar i publikationen
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Infection, Genet ...
- Av lärosätet
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Linköpings universitet
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Karolinska Institutet