onr:"swepub:oai:DiVA.org:liu-143342"
Search: onr:"swepub:oai:DiVA.org:liu-143342" > Aptamers as a model...
- 1 of 1
- Previous record
- Next record
- To hitlist
Aptamers as a model for functional evaluation of LNA and 2′-amino LNA
-
- Hernandez, Frank J (author)
- Nucleic Acid Center, Biochemistry and Molecular Biology Department, University of of Southern Denmark, Campusvej 55, Odense M, 5230, Denmark
-
- Kalra, Neerja (author)
- Department of Physics and Chemistry, University of of Southern Denmark, Campusvej 55, Odense M, 5230, Denmark
-
- Wengel, Jesper (author)
- Department of Physics and Chemistry, University of of Southern Denmark, Campusvej 55, Odense M, 5230, Denmark
- show more...
- show less...
- (creator_code:org_t)
- Pergamon Press, 2009
- 2009
- English.
- In: Bioorganic & Medicinal Chemistry Letters. - : Pergamon Press. - 0960-894X .- 1464-3405. ; 19:23, s. 6585-6587
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The affinity change upon incorporation of LNA and 2′-amino-LNA monomers into an avidin binding DNA aptamer is described. The kinetic profile of selected modified-aptamer was obtained by surface plasmon resonance experiments and compared with the profile of the parent unmodified DNA aptamer. We report significant improvement of avidin binding affinity by the incorporation of single LNA modifications into the aptamer, and successful incorporation of 2′-amino LNA as a novel monomer in aptamers with potential function as carrier unit for additional molecular entities. © 2009 Elsevier Ltd. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
Keyword
- 2′-Amino-LNA; Affinity; Aptamer; LNA; Surface plasmon resonance
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Bioorganic & Medicinal Chemistry Letters (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Hernandez, Frank ...
- Kalra, Neerja
- Wengel, Jesper
- Vester, Birte
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Other Basic Medi ...
- Articles in the publication
- Bioorganic & Med ...
- By the university
- Linköping University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
