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Stk33 is required for spermatid differentiation and male fertility in mice

Martins, Leila R. (author)
Division of Applied Functional Genomics, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, 69120 Heidelberg, Germany
Bung, Raffaela K. (author)
Division of Applied Functional Genomics, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, 69120 Heidelberg, Germany
Koch, Stefan (author)
Division of Molecular Embryology, DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany
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Richter, Karsten (author)
Core Facility Electron Microscopy, DKFZ, 69120 Heidelberg, Germany
Schwarzmüller, Laura (author)
Division of Applied Functional Genomics, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, 69120 Heidelberg, Germany
Terhardt, Dorothee (author)
Division of Applied Functional Genomics, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, 69120 Heidelberg, Germany
Kurtulmus, Bahtiyar (author)
Molecular Biology of Centrosomes and Cilia Unit, DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany
Niehrs, Christof (author)
Division of Molecular Embryology, DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany; Institute of Molecular Biology (IMB), 55128 Mainz, Germany
Rouhi, Arefeh (author)
Department of Internal Medicine III, Ulm University, 89081 Ulm, Germany
Lohmann, Ingrid (author)
Department of Developmental Biology, Centre for Organismal Studies (COS), 69120 Heidelberg, Germany
Pereira, Gislene (author)
Molecular Biology of Centrosomes and Cilia Unit, DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany
Fröhling, Stefan (author)
Division of Translational Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Section for Personalized Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany ; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
Glimm, Hanno (author)
Division of Translational Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
Scholl, Claudia (author)
Division of Applied Functional Genomics, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
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 (creator_code:org_t)
Academic Press, 2018
2018
English.
In: Developmental Biology. - : Academic Press. - 0012-1606 .- 1095-564X. ; 433:1, s. 84-93
Related links:
https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Spermiogenesis is the final phase during sperm cell development in which round spermatids undergo dramatic morphological changes to generate spermatozoa. Here we report that the serine/threonine kinase Stk33 is essential for the differentiation of round spermatids into functional sperm cells and male fertility. Constitutive Stk33 deletion in mice results in severely malformed and immotile spermatozoa that are particularly characterized by disordered structural tail elements. Stk33 expression first appears in primary spermatocytes, and targeted deletion of Stk33 in these cells recapitulates the defects observed in constitutive knockout mice, confirming a germ cell-intrinsic function. Stk33 protein resides in the cytoplasm and partially co-localizes with the caudal end of the manchette, a transient structure that guides tail elongation, in elongating spermatids, and loss of Stk33 leads to the appearance of a tight, straight and elongated manchette. Together, these results identify Stk33 as an essential regulator of spermatid differentiation and male fertility.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)

Keyword

Stk33
Kinase
Spermiogenesis
Spermatogenesis
Infertility
Manchette

Publication and Content Type

ref (subject category)
art (subject category)

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