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Activation-induced ...
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Lundberg, AnnaLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten
(author)
Activation-induced FOXP3 isoform profile in peripheral CD4+T cells is associated with coronary artery disease
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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ELSEVIER IRELAND LTD,2017
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:liu-143616
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-143616URI
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https://doi.org/10.1016/j.atherosclerosis.2017.10.026DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:137098503URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Swedish Research Council [349-2007-8703]; Swedish Heart-Lung Foundation; Foundation for Strategic Research (SSF); Vinnova Foundation; Stockholm County Council; European Commission (project Athero-Flux); European Commission (project VIA); [06816]
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Background and aims: The expression of FOXP3 isoforms affects regulatory T (Treg) cell function. Reduced Treg cell function has been associated with coronary artery disease (CAD). However, alternative splicing of FOXP3 in CAD has not been investigated. Methods: FOXP3 splice variants and IL17A transcripts in peripheral blood mononuclear cells from stable CAD patients and healthy controls were quantified, and FOXP3 isoform expression in response to T cell receptor (TCR) stimulation or LDL was analyzed by flow cytometry. Results: Compared to healthy controls, CAD patients expressed significantly more FOXP3 transcripts that included exon 2, whereas alternative splicing of exon 7 in correlation with IL17A expression was reduced. Moreover, TCR stimulation, as well as exposure to LDL, decreased alternative splicing of FOXP3 in CD4+ T cells in vitro. Conclusions: Our results demonstrate that blood mononuclear cells in stable CAD patients express a ratio of FOXP3 isoforms that is characteristic for activated CD4+ T cells. (C) 2017 Elsevier B.V. All rights reserved.
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Jonasson, LenaLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)lenjo59
(author)
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Hansson, Göran K.Karolinska Institutet,Karolinska University Hospital, Sweden
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Mailer, Reiner K. W.Karolinska University Hospital, Sweden
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Linköpings universitetAvdelningen för kardiovaskulär medicin
(creator_code:org_t)
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In:Atherosclerosis: ELSEVIER IRELAND LTD267, s. 27-330021-91501879-1484
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