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Systemic Th1/Th2 cy...
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Jonsson, YvonneLinköpings universitet,Klinisk immunologi,Hälsouniversitetet
(author)
Systemic Th1/Th2 cytokine responses to paternal and vaccination antigens in preeclampsia: no differences compared with normal pregnancy
- Article/chapterEnglish2004
Publisher, publication year, extent ...
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2004-03-16
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John Wiley & Sons,2004
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-14372
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-14372URI
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https://doi.org/10.1111/j.1600-0897.2004.00161.xDOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Problem: A Th1-shift has been suggested to be involved in the pathogenesis of preeclampsia. This study was designed to compare Th1/Th2 related cytokine secretion in blood between women with preeclampsia (n = 15) and normal pregnancies (n = 15), using a high-sensitivity technique for cytokine detection.Methods of study: Spontaneous as well as 'fetus-specific' and recall antigen-specific (purified protein derivate of Mycobacterium tuberculosis, tetanus toxoid and lipopolysaccharide) secretion of interferon-γ, interleukin (IL)-4, IL-10 and IL-12 in peripheral blood mononuclear cells (PBMC) was detected by enzyme-linked immunosorbent spot-forming cell assay (ELISPOT). Fetus-specific secretion was induced by stimulation with paternal PBMC in a mixed leukocyte culture assay.Results: All cytokines were secreted by PBMCs both from women with preeclampsia and women with normal pregnancies. No differences in the number of cytokine-secreting cells were found between the two groups.Conclusions: No evidence was found for a shift in the systemic Th1/Th2 responses, in preeclampsia compared with normal pregnancy. This does, however, not exclude differences in the local immune responses related to the fetoplacental unit.
Subject headings and genre
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ELISPOT
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interferon-γ
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interleukin-10
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interleukin-12
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interleukin-4
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preeclampsia
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Ekerfelt, ChristinaLinköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet(Swepub:liu)chrek55
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Berg, GöranÖstergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping(Swepub:liu)gorbe09
(author)
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Nieminen, KatriLinköpings universitet,Institutionen för molekylär och klinisk medicin,Hälsouniversitetet(Swepub:liu)katni97
(author)
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Sharma, SurendraDepartments of Pediatrics and Pathology, Brown University and Women and Infants' Hospital of Rhode Island, Providence, RI, USA
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Ernerudh, JanÖstergötlands Läns Landsting,Linköpings universitet,Klinisk immunologi,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin(Swepub:liu)janer15
(author)
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Linköpings universitetKlinisk immunologi
(creator_code:org_t)
Related titles
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In:American Journal of Reproductive Immunology: John Wiley & Sons51:4, s. 302-3101046-74081600-0897
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