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Flt3 ligand expands...
Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo
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- Parigi, Sara M. (author)
- Karolinska Institute, Sweden; University Hospital, Sweden
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- Czarnewski, Paulo (author)
- Karolinska Institute, Sweden; University Hospital, Sweden
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- Das, Srustidhar (author)
- Karolinska Institutet
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- Steeg, Christiane (author)
- Bernhard Nocht Institute Trop Med, Germany
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- Brockmann, Leonie (author)
- 9 Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Fernandez-Gaitero, Sara (author)
- Karolinska Institute, Sweden; University Hospital, Sweden
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- Yman, Victor (author)
- Karolinska Institutet
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- Forkel, Marianne (author)
- Karolinska Institute, Sweden
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- Höög, Charlotte (author)
- Karolinska Institutet
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- Mjösberg, Jenny (author)
- Karolinska Institutet,Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Karolinska Institute, Sweden
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- Westerberg, Lisa (author)
- Karolinska Institutet
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- Färnert, Anna (author)
- Karolinska Institutet
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- Huber, Samuel (author)
- University of Medical Centre Hamburg Eppendorf, Germany
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- Jacobs, Thomas (author)
- Bernhard Nocht Institute Trop Med, Germany
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- Villablanca, Eduardo J. (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2018-01-09
- 2018
- English.
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In: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 8
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Abstract
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- A common helper-like innate lymphoid precursor (CHILP) restricted to the innate lymphoid cells (ILC) lineage has been recently characterized. While specific requirements of transcription factors for CHILPs development has been partially described, their ability to sense cytokines and react to peripheral inflammation remains unaddressed. Here, we found that systemic increase in Flt3L levels correlated with the expansion of Lineage (Lin)(neg)alpha 4 beta 7(+) precursors in the adult murine bone marrow. Expanded Lin(neg)alpha 4 beta 7(+) precursors were bona fide CHILPs as seen by their ability to differentiate into all helper ILCs subsets but cNK in vivo. Interestingly, Flt3L-expanded CHILPs transferred into lymphopenic mice preferentially reconstituted the small intestine. While we did not observe changes in serum Flt3L during DSS-induced colitis in mice or plasma from inflammatory bowel disease (IBD) patients, elevated Flt3L levels were detected in acute malaria patients. Interestingly, while CHILP numbers were stable during the course of DSS-induced colitis, they expanded following increased serum Flt3L levels in malaria-infected mice, hence suggesting a role of the Flt3L-ILC axis in malaria. Collectively, our results indicate that Flt3L expands CHILPs in the bone marrow, which might be associated with specific inflammatory conditions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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- art (subject category)
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- By the author/editor
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Parigi, Sara M.
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Czarnewski, Paul ...
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Das, Srustidhar
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Steeg, Christian ...
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Brockmann, Leoni ...
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Fernandez-Gaiter ...
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show more...
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Yman, Victor
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Forkel, Marianne
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Höög, Charlotte
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Mjösberg, Jenny
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Westerberg, Lisa
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Färnert, Anna
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Huber, Samuel
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Jacobs, Thomas
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Villablanca, Edu ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Scientific Repor ...
- By the university
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Linköping University
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Karolinska Institutet