A time–response model for analysis of drug transport and blood flow response during iontophoresis of acetylcholine and sodium nitroprusside

Tesselaar (Droog), ErikLinköpings universitet,Institutionen för medicin och vård,Hälsouniversitetet (author)

Background/Aims: The analysis of blood flow responses to iontophoresis of vasoactive drugs is often limited to evaluation of maximum responses. In this study, a time-response model is proposed for the blood flow responses to vasoactive drugs applied by iontophoresis. Methods: The microvascular bed is represented as a single compartment with a zero-order influx of the drugs from the electrode and a first-order clearance due to diffusion and blood flow. The blood flow response to the local drug dose is described using the Emax model. Results: The model accurately describes the blood flow responses to acetylcholine and sodium nitroprusside during a single iontophoretic current pulse. There is a significant clearance out of the microvascular bed during iontophoresis which depends on the type of drug administered. Conclusion: The model enables an accurate estimation of response parameters such as ED50 and maximum response, even if the true maximum blood flow is not obtained. The results suggest that due to clearance from the microvascular bed, the local drug dose during a single pulse of current is not linearly proportional to current strength multiplied by pulse duration.

Henricson, JoakimLinköpings universitet,Institutionen för biomedicin och kirurgi,Hälsouniversitetet(Swepub:liu)joahe08 (author)
Jonsson, SusanneLinköpings universitet,Institutionen för medicin och vård,Hälsouniversitetet (author)
Sjöberg, FolkeÖstergötlands Läns Landsting,Linköpings universitet,Institutionen för biomedicin och kirurgi,Hälsouniversitetet,Hand- och plastikkirurgiska kliniken US(Swepub:liu)folsj94 (author)
Linköpings universitetInstitutionen för medicin och vård (creator_code:org_t)

In:Journal of Vascular ResearchBasel, Switzerland : S. Karger46:4, s. 270-2771018-11721423-0135

By the author/editor: Tesselaar (Droog ...; Henricson, Joaki ...; Jonsson, Susanne; Sjöberg, Folke

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.