SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:liu-147432"
 

Search: onr:"swepub:oai:DiVA.org:liu-147432" > Daily home BNP moni...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • McDonald, KennethSt Vincents Univ Hosp, Ireland; Univ Coll Dublin, Ireland (author)

Daily home BNP monitoring in heart failure for prediction of impending clinical deterioration: results from the HOME HF study

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-01-04
  • WILEY,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-147432
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-147432URI
  • https://doi.org/10.1002/ejhf.1053DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Alere
  • Background Serial measurement of natriuretic peptides may guide management in heart failure (HF) patients. In previous trials, natriuretic peptides were infrequently monitored, which may undervalue the benefit of this approach. Methods and results HOME was an adaptive three-arm randomized clinical study to test whether home monitoring of BNP could reduce HF-related death, hospitalization due to acute decompensated HF (ADHF), and ADHF treated with intravenous diuretics in the emergency department or outpatient setting. Enrolment was terminated early because of slow enrolment, low event rates, and the belief that an algorithm for assessing BNP trends was needed. Justification for pooling data from all study arms was made and analysis as a single observational study was performed. The analysis resulted in 107 patients who were monitored for a median of 172 days with BNP measures on a median of 74% of days. BNP values were highly variable within a patient. Dispersion between serial BNPs was calculated to be 39.3%, 57.7%, and 73.6% for 1, 60, and 120 days between measures, respectively. A moving average filter (fBNP) was calculated to reduce day-to-day fluctuations and track changes from week to week. There were 27 primary events in 17 362 patient days of monitoring; the hazard ratio for time-varying fBNP was 2.22 (95% confidence interval 1.48-3.34) per unit natural log (corresponding to a 2.72-fold change in fBNP level). Conclusion The HOME HF study demonstrates the feasibility of home BNP measurement and shows the potential value of fBNP as an index of emerging clinical deterioration. Assessment of the clinical value of this is required.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Troughton, RichardUniv Otago, New Zealand (author)
  • Dahlström, UlfLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)ulfda85 (author)
  • Dargie, HenryUniv Glasgow, Scotland (author)
  • Krum, HenryMonash Univ, Australia (author)
  • van der Meer, PeterUniv Med Ctr Groningen, Netherlands (author)
  • McDonagh, TheresaKings Coll Hosp London, England (author)
  • Atherton, John J.Royal Brisbane Hosp, Australia; Univ Queensland, Australia (author)
  • Kupfer, KenAlere, CA USA (author)
  • George, Richard C. SanAlere, CA USA (author)
  • Richards, MarkUniv Otago, New Zealand (author)
  • Doughty, RobertUniv Auckland, New Zealand (author)
  • St Vincents Univ Hosp, Ireland; Univ Coll Dublin, IrelandUniv Otago, New Zealand (creator_code:org_t)

Related titles

  • In:European Journal of Heart Failure: WILEY20:3, s. 474-4801388-98421879-0844

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view