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Expression of PRL p...
Expression of PRL proteins at invasive margin of rectal cancers in relation to preoperative radiotherapy
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- Wallin, Åsa R., 1976- (author)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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- Svanvik, Joar (author)
- Linköpings universitet,Kirurgi,Hälsouniversitetet
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- Adell, Gunnar (author)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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- Sun, Xiao-Feng (author)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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(creator_code:org_t)
- Elsevier BV, 2006
- 2006
- English.
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In: International Journal of Radiation Oncology, Biology, Physics. - : Elsevier BV. - 0360-3016 .- 1879-355X. ; 65:2, s. 452-458
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http://urn.kb.se/res...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Purpose: PRL-3 (phosphatase of regenerating liver) is involved in metastasis of colorectal cancer; however, its therapeutic implication in cancer patients has not been studied. We investigated the relationships of PRL expression to radiotherapy (RT) in rectal cancer patients.Methods and Materials: Phosphatase of regenerating liver expression was immunohistochemically examined in distant (n = 36) and adjacent (n = 82) normal mucosa, primary tumor (n = 125), biopsy specimens (n = 96), and lymph node metastasis (n = 30) from rectal cancer patients participating in a clinical trial of preoperative RT.Results: Phosphatase of regenerating liver expression was increased from the distant to adjacent mucosa and to the primary tumor (p < 0.05). PRL was highly expressed at the invasive margin in 28% of the primary tumors and 26% of the metastases. In the RT group, strong PRL expression at the invasive margin was related to distant recurrence (p = 0.006) and poor survival (p = 0.01), but not in the non-RT group. The survival significance remained even after adjusting for Dukes’ stage and differentiation (p = 0.02). Additional multivariate analyses showed that the correlation with prognostic significance of PRL differed between the RT and non-RT groups (p = 0.01).Conclusion: Phosphatase of regenerating liver expression (rather than PRL-3 alone) at the invasive margin predicted resistance to RT and unfavorable survival in rectal cancer patients with preoperative RT.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Phosphatase of regenerating liver; PRL; Invasive margin; Radiotherapy; Prognosis; Rectal cancer
- Oncology
- Onkologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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