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Cerium oxide nanopa...
Cerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for MRI contrast enhancement
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- Eriksson, Peter (author)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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- Tal, Alexey (author)
- Linköpings universitet,Teoretisk Fysik,Tekniska fakulteten
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- Skallberg, Andreas (author)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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- Brommesson, Caroline (author)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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- Hu, Zhang-Jun (author)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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- Boyd, Robert (author)
- Linköpings universitet,Plasma och ytbeläggningsfysik,Tekniska fakulteten
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- Olovsson, Weine (author)
- Linköpings universitet,Teoretisk Fysik,Tekniska fakulteten
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- Fairley, Neal (author)
- Casa Software Ltd, Bay House, Teignmouth, United Kingdom
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- Abrikosov, Igor (author)
- Linköpings universitet,Teoretisk Fysik,Tekniska fakulteten,Materials Modeling and Development Laboratory, National University of Science and Technology “MISIS”, Moscow, Russia
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- Zhang, Xuanjun (author)
- Faculty of Health Sciences, University of Macau, Macau, SAR, China
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- Uvdal, Kajsa (author)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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(creator_code:org_t)
- 2018-05-03
- 2018
- English.
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In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 8
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Abstract
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- The chelating gadolinium-complex is routinely used as magnetic resonance imaging (MRI) -contrast enhancer. However, several safety issues have recently been reported by FDA and PRAC. There is an urgent need for the next generation of safer MRI-contrast enhancers, with improved local contrast and targeting capabilities. Cerium oxide nanoparticles (CeNPs) are designed with fractions of up to 50% gadolinium to utilize the superior MRI-contrast properties of gadolinium. CeNPs are well-tolerated in vivo and have redox properties making them suitable for biomedical applications, for example scavenging purposes on the tissue-and cellular level and during tumor treatment to reduce in vivo inflammatory processes. Our near edge X-ray absorption fine structure (NEXAFS) studies show that implementation of gadolinium changes the initial co-existence of oxidation states Ce3+ and Ce4+ of cerium, thereby affecting the scavenging properties of the nanoparticles. Based on ab initio electronic structure calculations, we describe the most prominent spectral features for the respective oxidation states. The as-prepared gadolinium-implemented CeNPs are 3-5 nm in size, have r(1)-relaxivities between 7-13 mM(-1) s(-1) and show clear antioxidative properties, all of which means they are promising theranostic agents for use in future biomedical applications.
Subject headings
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Eriksson, Peter
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Tal, Alexey
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Skallberg, Andre ...
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Brommesson, Caro ...
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Hu, Zhang-Jun
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Boyd, Robert
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show more...
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Olovsson, Weine
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Fairley, Neal
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Abrikosov, Igor
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Zhang, Xuanjun
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Uvdal, Kajsa
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Physical Science ...
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and Other Physics To ...
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Scientific Repor ...
- By the university
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Linköping University