Search: onr:"swepub:oai:DiVA.org:liu-147922" >
Complement-Opsonize...
-
Ellegård, Rada,1985-Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Region Östergötland, Klinisk genetik
(author)
Complement-Opsonized HIV-1 Alters Cross Talk Between Dendritic Cells and Natural Killer (NK) Cells to Inhibit NK Killing and to Upregulate PD-1, CXCR3, and CCR4 on T Cells
- Article/chapterEnglish2018
Publisher, publication year, extent ...
-
2018-04-30
-
FRONTIERS MEDIA SA,2018
-
electronicrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:liu-147922
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-147922URI
-
https://doi.org/10.3389/fimmu.2018.00899DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Funding Agencies|Swedish Research Council; Swedish Physicians against AIDS Research Foundation; VINNMER for Vinnova; Linkoping University Hospital Research Fund; ALF Grants Region Ostergotland; FORSS; CERiA, University of Malaya [UM.C.625/1/HIR/139]
-
Dendritic cells (DCs), natural killer (NK) cells, and T cells play critical roles during primary HIV-1 exposure at the mucosa, where the viral particles become coated with complement fragments and mucosa-associated antibodies. The microenvironment together with subsequent interactions between these cells and HIV at the mucosal site of infection will determine the quality of immune response that ensues adaptive activation. Here, we investigated how complement and immunoglobulin opsonization influences the responses triggered in DCs and NK cells, how this affects their cross talk, and what T cell phenotypes are induced to expand following the interaction. Our results showed that DCs exposed to complement-opsonized HIV (C-HIV) were less mature and had a poor ability to trigger IFN-driven NK cell activation. In addition, when the DCs were exposed to C-HIV, the cytotolytic potentials of both NK cells and CD8 T cells were markedly suppressed. The expression of PD-1 as well as co-expression of negative immune checkpoints TIM-3 and LAG-3 on PD-1 positive cells were increased on both CD4 as well as CD8 T cells upon interaction with and priming by NK-DC cross talk cultures exposed to C-HIV. In addition, stimulation by NK-DC cross talk cultures exposed to C-HIV led to the upregulation of CD38, CXCR3, and CCR4 on T cells. Together, the immune modulation induced during the presence of complement on viral surfaces is likely to favor HIV establishment, dissemination, and viral pathogenesis.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Khalid, MohammadLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,King Khalid Univ, Saudi Arabia(Swepub:liu)mohkh49
(author)
-
Svanberg, CeciliaLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten(Swepub:liu)cecsv36
(author)
-
Holgersson, HannaLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten(Swepub:liu)n/a
(author)
-
Thoren, YlvaLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten(Swepub:liu)n/a
(author)
-
Wittgren, Mirja KarolinaLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten(Swepub:liu)n/a
(author)
-
Hinkula, JormaLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten(Swepub:liu)jorhi40
(author)
-
Nyström, SofiaLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin(Swepub:liu)sofny82
(author)
-
Shankar, Esaki M.Univ Malaya, Malaysia; Cent Univ Tamil Nadu, India
(author)
-
Larsson, MarieLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten(Swepub:liu)marla67
(author)
-
Linköpings universitetAvdelningen för mikrobiologi och molekylär medicin
(creator_code:org_t)
Related titles
-
In:Frontiers in Immunology: FRONTIERS MEDIA SA91664-3224
Internet link
Find in a library
To the university's database
- By the author/editor
-
Ellegård, Rada, ...
-
Khalid, Mohammad
-
Svanberg, Cecili ...
-
Holgersson, Hann ...
-
Thoren, Ylva
-
Wittgren, Mirja ...
-
show more...
-
Hinkula, Jorma
-
Nyström, Sofia
-
Shankar, Esaki M ...
-
Larsson, Marie
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Immunology
- Articles in the publication
-
Frontiers in Imm ...
- By the university
-
Linköping University