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The qualitative gra...
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Abbott, RebeccaNorthwestern Univ, IL 60611 USA
(author)
The qualitative grading of muscle fat infiltration in whiplash using fat and water magnetic resonance imaging
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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ELSEVIER SCIENCE INC,2018
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-148257
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148257URI
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https://doi.org/10.1016/j.spinee.2017.08.233DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Funding Agencies|Swedish Research Council [521-2014-2982]; Medical Research Council of South-East Sweden [FORSS 225601, FORSS 391021, FORSS 311941]
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BACKGROUND CONTEXT: The development of muscle fat infiltration (MFI) in the neck muscles is associated with poor functional recovery following whiplash injury. Custom software and time-consuming manual segmentation of magnetic resonance imaging (MRI) is required for quantitative analysis and presents as a barrier for clinical translation. PURPOSE: The purpose of this work was to establish a qualitative MRI measure for MFI and evaluate its ability to differentiate between individuals with severe whiplash-associated disorder (WAD), mild or moderate WAD, and healthy controls. STUDY DESIGN/SETTING: This is a cross-sectional study. PATIENT SAMPLE: Thirty-one subjects with WAD and 31 age-and sex-matched controls were recruited from an ongoing randomized controlled trial. OUTCOME MEASURES: The cervical multifidus was visually identified and segmented into eighths in the axial fat/water images (C4-C7). Muscle fat infiltration was assessed on a visual scale: 0 for no or marginal MFI, 1 for light MFI, and 2 for distinct MFI. The participants with WAD were divided in two groups: mild or moderate and severe based on Neck Disability Index % scores. METHODS: The mean regional MFI was compared between the healthy controls and each of the WAD groups using the Mann-Whitney U test. Receiver operator characteristic (ROC) analyses were carried out to evaluate the validity of the qualitative method. RESULTS: Twenty (65%) patients had mild or moderate disability and 11 (35%) were considered severe. Inter- and intra-rater reliability was excellent when grading was averaged by level or when frequency of grade II was considered. Statistically significant differences (pamp;lt;.05) in regional MFI were particularly notable between the severe WAD group and healthy controls. The ROC curve, based on detection of distinct MFI, showed an area-under-the curve of 0.768 (95% confidence interval 0.59-0.94) for discrimination of WAD participants. CONCLUSIONS: These preliminary results suggest a qualitative MRI measure for MFI is reliable and valid, and may prove useful toward the classification of WAD in radiology practice. (C) 2017 Elsevier Inc. All rights reserved.
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Peolsson, AnneliLinköpings universitet,Avdelningen för fysioterapi,Medicinska fakulteten(Swepub:liu)annpe35
(author)
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West, Janne,1982-Linköpings universitet,Avdelningen för radiologiska vetenskaper,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinska fakulteten(Swepub:liu)janwe85
(author)
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Elliott, James M.Northwestern Univ, IL 60611 USA; Univ Queensland, Australia; Zurich Univ Appl Sci, Switzerland
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Åslund, UlrikaLinköpings universitet,Avdelningen för fysioterapi,Medicinska fakulteten(Swepub:liu)n/a
(author)
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Karlsson, AnetteLinköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV(Swepub:liu)aneka89
(author)
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Dahlqvist Leinhard, Olof,1978-Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Radiofysikavdelningen US(Swepub:liu)oloda24
(author)
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Northwestern Univ, IL 60611 USAAvdelningen för fysioterapi
(creator_code:org_t)
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In:The spine journal: ELSEVIER SCIENCE INC18:5, s. 717-7251529-94301878-1632
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