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A relationship betw...
A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans
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- Aoun, E. G. (author)
- Brown Univ, RI 02912 USA
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- Jimenez, V. A. (author)
- Oregon Hlth and Sci Univ, OR 97201 USA
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- Vendruscolo, L. F. (author)
- Scripps Res Inst, CA 92037 USA; NIDA, MD 20892 USA
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- Walter, N. A. R. (author)
- Oregon Hlth and Sci Univ, OR 97201 USA
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- Barbier, Estelle, 1980- (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten
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- Ferrulli, A. (author)
- Univ Cattolica Sacro Cuore, Italy
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- Haass-Koffler, C. L. (author)
- Brown Univ, RI 02912 USA; NIAAA, MD 20892 USA; NIDA, MD 20892 USA
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- Darakjian, P. (author)
- Oregon Hlth and Sci Univ, OR 97201 USA
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- Lee, M. R. (author)
- NIAAA, MD 20892 USA; NIDA, MD 20892 USA
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- Addolorato, G. (author)
- Univ Cattolica Sacro Cuore, Italy
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- Heilig, Markus, 1959- (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken
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- Hitzemann, R. (author)
- Oregon Hlth and Sci Univ, OR 97201 USA
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- Koob, G. F. (author)
- Scripps Res Inst, CA 92037 USA; NIAAA, MD 20852 USA
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- Grant, K. A. (author)
- Oregon Hlth and Sci Univ, OR 97201 USA
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- Leggio, L. (author)
- Brown Univ, RI 02912 USA; NIAAA, MD 20892 USA; NIDA, MD 20892 USA
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(creator_code:org_t)
- 2017-05-02
- 2018
- English.
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In: Molecular Psychiatry. - : NATURE PUBLISHING GROUP. - 1359-4184 .- 1476-5578. ; 23:6, s. 1466-1473
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Abstract
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- Aldosterone regulates electrolyte and fluid homeostasis through binding to the mineralocorticoid receptors (MRs). Previous work provides evidence for a role of aldosterone in alcohol use disorders (AUDs). We tested the hypothesis that high functional activity of the mineralocorticoid endocrine pathway contributes to vulnerability for AUDs. In Study 1, we investigated the relationship between plasma aldosterone levels, ethanol self-administration and the expression of CYP11B2 and MR (NR3C2) genes in the prefrontal cortex area (PFC) and central nucleus of the amygdala (CeA) in monkeys. Aldosterone significantly increased after 6- and 12-month ethanol self-administration. NR3C2 expression in the CeA was negatively correlated to average ethanol intake during the 12 months. In Study 2, we measured Nr3c2 mRNA levels in the PFC and CeA of dependent and nondependent rats and the correlates with ethanol drinking during acute withdrawal. Low Nr3c2 expression levels in the CeA were significantly associated with increased anxiety-like behavior and compulsive-like drinking in dependent rats. In Study 3, the relationship between plasma aldosterone levels, alcohol drinking and craving was investigated in alcohol-dependent patients. Non-abstinent patients had significantly higher aldosterone levels than abstinent patients. Aldosterone levels positively correlated with the number of drinks consumed, craving and anxiety scores. These findings support a relationship between ethanol drinking and the aldosterone/MR pathway in three different species.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Aoun, E. G.
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Jimenez, V. A.
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Vendruscolo, L. ...
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Walter, N. A. R.
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Barbier, Estelle ...
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Ferrulli, A.
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show more...
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Haass-Koffler, C ...
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Darakjian, P.
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Lee, M. R.
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Addolorato, G.
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Heilig, Markus, ...
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Hitzemann, R.
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Koob, G. F.
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Grant, K. A.
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Leggio, L.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Molecular Psychi ...
- By the university
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Linköping University