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Perspectives for pe...
Perspectives for personalized therapy for patients with multidrug-resistant tuberculosis
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- Lange, C. (author)
- Karolinska Institutet,Res Ctr Borstel, Germany; German Ctr Infect Res DZIF, Germany; Univ Lubeck, Germany; Karolinska Inst, Sweden
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- Alghamdi, W. A. (author)
- Univ Florida, FL USA
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- Al-Shaer, M. H. (author)
- Univ Florida, FL USA,German Ctr Infect Res DZIF, Germany; Res Ctr Borstel, Germany,Natl Reference Ctr Mycobacteria, Germany
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- Brighenti, S. (author)
- Karolinska Institutet,Karolinska Univ Hosp Huddinge, Sweden
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- Diacon, A. H. (author)
- Task Appl Sci, South Africa; Stellenbosch Univ, South Africa
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- DiNardo, A. R. (author)
- Baylor Coll Med, TX 77030 USA
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- Grobbel, H. P. (author)
- Res Ctr Borstel, Germany; German Ctr Infect Res DZIF, Germany; Univ Lubeck, Germany
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- Groschel, M. I. (author)
- Univ Groningen, Netherlands; Natl Reference Ctr Mycobacteria, Germany
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- von Groote-Bidlingmaier, F. (author)
- Task Appl Sci, South Africa
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- Hauptmann, M. (author)
- German Ctr Infect Res DZIF, Germany; Res Ctr Borstel, Germany
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- Heyckendorf, J. (author)
- Res Ctr Borstel, Germany; German Ctr Infect Res DZIF, Germany; Univ Lubeck, Germany
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- Kohler, N. (author)
- Res Ctr Borstel, Germany; German Ctr Infect Res DZIF, Germany; Univ Lubeck, Germany
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- Kohl, T. A. (author)
- Natl Reference Ctr Mycobacteria, Germany,Bernhard Nocht Inst Trop Med, Germany
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- Merker, M. (author)
- Natl Reference Ctr Mycobacteria, Germany,Res Ctr Borstel, Germany; German Ctr Infect Res DZIF, Germany; Univ Lubeck, Germany
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- Niemann, S. (author)
- German Ctr Infect Res DZIF, Germany; Natl Reference Ctr Mycobacteria, Germany
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- Peloquin, C. A. (author)
- Univ Florida, FL USA
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- Reimann, M. (author)
- Res Ctr Borstel, Germany; German Ctr Infect Res DZIF, Germany; Univ Lubeck, Germany
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- Schaible, U. E. (author)
- German Ctr Infect Res DZIF, Germany; Res Ctr Borstel, Germany; Univ Lubeck, Germany; LRA INFECTIONS 21, Germany
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- Schaub, D. (author)
- Res Ctr Borstel, Germany; German Ctr Infect Res DZIF, Germany; Univ Lubeck, Germany
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- Schleusener, V. (author)
- Natl Reference Ctr Mycobacteria, Germany
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- Thye, T. (author)
- Bernhard Nocht Inst Trop Med, Germany
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- Schön, Thomas (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Department of Clinical Microbiology and Infectious Diseases, Kalmar County Hospital
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(creator_code:org_t)
- 2018-07-11
- 2018
- English.
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In: Journal of Internal Medicine. - : WILEY. - 0954-6820 .- 1365-2796. ; 284:2, s. 163-188
- Related links:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- According to the World Health Organization (WHO), tuberculosis is the leading cause of death attributed to a single microbial pathogen worldwide. In addition to the large number of patients affected by tuberculosis, the emergence of Mycobacterium tuberculosis drug-resistance is complicating tuberculosis control in many high-burden countries. During the past 5years, the global number of patients identified with multidrug-resistant tuberculosis (MDR-TB), defined as bacillary resistance at least against rifampicin and isoniazid, the two most active drugs in a treatment regimen, has increased by more than 20% annually. Today we experience a historical peak in the number of patients affected by MDR-TB. The management of MDR-TB is characterized by delayed diagnosis, uncertainty of the extent of bacillary drug-resistance, imprecise standardized drug regimens and dosages, very long duration of therapy and high frequency of adverse events which all translate into a poor prognosis for many of the affected patients. Major scientific and technological advances in recent years provide new perspectives through treatment regimens tailor-made to individual needs. Where available, such personalized treatment has major implications on the treatment outcomes of patients with MDR-TB. The challenge now is to bring these adances to those patients that need them most.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
Keyword
- individualized medicine; MDR-TB; personalized medicine; XDR-TB
Publication and Content Type
- ref (subject category)
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- By the author/editor
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Lange, C.
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Alghamdi, W. A.
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Al-Shaer, M. H.
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Brighenti, S.
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Diacon, A. H.
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DiNardo, A. R.
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show more...
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Grobbel, H. P.
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Groschel, M. I.
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von Groote-Bidli ...
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Hauptmann, M.
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Heyckendorf, J.
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Kohler, N.
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Kohl, T. A.
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Merker, M.
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Niemann, S.
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Peloquin, C. A.
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Reimann, M.
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Schaible, U. E.
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Schaub, D.
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Schleusener, V.
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Thye, T.
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Schön, Thomas
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and General Practice
- Articles in the publication
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Journal of Inter ...
- By the university
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Linköping University
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Karolinska Institutet