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Perspectives for pe...
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Lange, C.Karolinska Institutet,Res Ctr Borstel, Germany; German Ctr Infect Res DZIF, Germany; Univ Lubeck, Germany; Karolinska Inst, Sweden
(author)
Perspectives for personalized therapy for patients with multidrug-resistant tuberculosis
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-07-11
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WILEY,2018
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:liu-150237
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-150237URI
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https://doi.org/10.1111/joim.12780DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:138790729URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
Notes
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Funding Agencies|German Center for Infection Research (DZIF); Swedish Research council; Swedish Heart and Lung Foundation (Oscar II Jubilee Foundation); South African National Research Foundation; Leibniz Research Campus EvoLung
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According to the World Health Organization (WHO), tuberculosis is the leading cause of death attributed to a single microbial pathogen worldwide. In addition to the large number of patients affected by tuberculosis, the emergence of Mycobacterium tuberculosis drug-resistance is complicating tuberculosis control in many high-burden countries. During the past 5years, the global number of patients identified with multidrug-resistant tuberculosis (MDR-TB), defined as bacillary resistance at least against rifampicin and isoniazid, the two most active drugs in a treatment regimen, has increased by more than 20% annually. Today we experience a historical peak in the number of patients affected by MDR-TB. The management of MDR-TB is characterized by delayed diagnosis, uncertainty of the extent of bacillary drug-resistance, imprecise standardized drug regimens and dosages, very long duration of therapy and high frequency of adverse events which all translate into a poor prognosis for many of the affected patients. Major scientific and technological advances in recent years provide new perspectives through treatment regimens tailor-made to individual needs. Where available, such personalized treatment has major implications on the treatment outcomes of patients with MDR-TB. The challenge now is to bring these adances to those patients that need them most.
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Alghamdi, W. A.Univ Florida, FL USA
(author)
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Al-Shaer, M. H.Univ Florida, FL USA,German Ctr Infect Res DZIF, Germany; Res Ctr Borstel, Germany,Natl Reference Ctr Mycobacteria, Germany
(author)
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Brighenti, S.Karolinska Institutet,Karolinska Univ Hosp Huddinge, Sweden
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Diacon, A. H.Task Appl Sci, South Africa; Stellenbosch Univ, South Africa
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DiNardo, A. R.Baylor Coll Med, TX 77030 USA
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Grobbel, H. P.Res Ctr Borstel, Germany; German Ctr Infect Res DZIF, Germany; Univ Lubeck, Germany
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Groschel, M. I.Univ Groningen, Netherlands; Natl Reference Ctr Mycobacteria, Germany
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von Groote-Bidlingmaier, F.Task Appl Sci, South Africa
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Hauptmann, M.German Ctr Infect Res DZIF, Germany; Res Ctr Borstel, Germany
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Heyckendorf, J.Res Ctr Borstel, Germany; German Ctr Infect Res DZIF, Germany; Univ Lubeck, Germany
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Kohler, N.Res Ctr Borstel, Germany; German Ctr Infect Res DZIF, Germany; Univ Lubeck, Germany
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Kohl, T. A.Natl Reference Ctr Mycobacteria, Germany,Bernhard Nocht Inst Trop Med, Germany
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Merker, M.Natl Reference Ctr Mycobacteria, Germany,Res Ctr Borstel, Germany; German Ctr Infect Res DZIF, Germany; Univ Lubeck, Germany
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Niemann, S.German Ctr Infect Res DZIF, Germany; Natl Reference Ctr Mycobacteria, Germany
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Peloquin, C. A.Univ Florida, FL USA
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Reimann, M.Res Ctr Borstel, Germany; German Ctr Infect Res DZIF, Germany; Univ Lubeck, Germany
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Schaible, U. E.German Ctr Infect Res DZIF, Germany; Res Ctr Borstel, Germany; Univ Lubeck, Germany; LRA INFECTIONS 21, Germany
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Schaub, D.Res Ctr Borstel, Germany; German Ctr Infect Res DZIF, Germany; Univ Lubeck, Germany
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Schleusener, V.Natl Reference Ctr Mycobacteria, Germany
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Thye, T.Bernhard Nocht Inst Trop Med, Germany
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Schön, ThomasLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Department of Clinical Microbiology and Infectious Diseases, Kalmar County Hospital(Swepub:liu)thosc49
(author)
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Karolinska InstitutetRes Ctr Borstel, Germany; German Ctr Infect Res DZIF, Germany; Univ Lubeck, Germany; Karolinska Inst, Sweden
(creator_code:org_t)
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In:Journal of Internal Medicine: WILEY284:2, s. 163-1880954-68201365-2796
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Lange, C.
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Alghamdi, W. A.
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Al-Shaer, M. H.
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Brighenti, S.
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Diacon, A. H.
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DiNardo, A. R.
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Grobbel, H. P.
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Groschel, M. I.
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von Groote-Bidli ...
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Hauptmann, M.
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Heyckendorf, J.
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Kohler, N.
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Kohl, T. A.
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Merker, M.
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Niemann, S.
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Peloquin, C. A.
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Reimann, M.
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Schaible, U. E.
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Schaub, D.
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Schleusener, V.
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Thye, T.
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Schön, Thomas
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Linköping University
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Karolinska Institutet