Prevalence of the apolipoprotein E epsilon 4 allele in amyloid beta positive subjects across the spectrum of Alzheimers disease

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Fältnamn	Indikatorer	Metadata
000		11053naa a2201453 4500
001		oai:DiVA.org:liu-150288
003		SwePub
008		180817s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1502882 URI
024	7	a https://doi.org/10.1016/j.jalz.2018.02.0092 DOI
040		a (SwePub)liu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Mattsson, Niklasu Lund Univ, Sweden4 aut
245	1 0	a Prevalence of the apolipoprotein E epsilon 4 allele in amyloid beta positive subjects across the spectrum of Alzheimers disease
264		c 2018-03-27
264	1	b ELSEVIER SCIENCE INC,c 2018
338		a print2 rdacarrier
500		a Funding Agencies\|AXA Research Fund; Fondation Universite Pierre et Marie Curie; "Fondation pour la Recherche sur Alzheimer", Paris, France; program "Investissements davenir" [ANR-10-IAIHU-06]; National Institutes of Health [P50 AG005133, RF1 AG025516, PO1 AG025204]; Marie Curie FP7 International Outgoing Fellowship [628812]; Instituto de Salud Carlos III (Fondo de InvestigaciOn Sanitario) [PI08/0139, PI12/02288, PI16/01652]; NIH/NIA [RF1 AG057570, AG035137, AG032554, AG022374, AG13616, AG12101, AG08051, NIH-HLB HL111724]; Instituto de Salud Carlos III (CIBERNED program)
520		a Introduction: Apolipoprotein E (APOE) epsilon 4 is the major genetic risk factor for Alzheimers disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid beta(A beta) pathology. Methods: We included 3451 A beta+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Generalized estimating equation models were used to assess APOE epsilon 4 prevalence in relation to age, sex, education, and geographical location. Results: The APOE epsilon 4 prevalence was 66% in AD-type dementia, 64% in mild cognitive impairment, and 51% in cognitively normal, and it decreased with advancing age in A beta+ cognitively normal and A beta+ mild cognitive impairment (P amp;lt;.05) but not in A beta+ AD dementia (P =.66). The prevalence was highest in Northern Europe but did not vary by sex or education. Discussion: The APOE E4 prevalence in AD was higher than that in previous studies, which did not require presence of A beta pathology. Furthermore, our results highlight disease heterogeneity related to age and geographical location. (C) 2018 the Alzheimers Association. Published by Elsevier Inc. All rights reserved.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Geriatrik0 (SwePub)302222 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Geriatrics0 (SwePub)302222 hsv//eng
653		a APOE; Prevalence; Amyloid; PET; CSF; Alzheimers disease; Mild cognitive impairment; Subjective cognitive decline; Age; Sex; Education; Geographical location
700	1	a Groot, Colinu Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands4 aut
700	1	a Jansen, Willemijn J.u Maastricht Univ, Netherlands4 aut
700	1	a Landau, Susan M.u Univ Calif Berkeley, CA 94720 USA4 aut
700	1	a Villemagne, Victor L.u Austin Hlth, Australia; Austin Hlth, Australia4 aut
700	1	a Engelborghs, Sebastiaanu Univ Antwerp, Belgium4 aut
700	1	a Mintun, Mark M.u Avid Radiopharmaceut, PA USA4 aut
700	1	a Lleo, Albertou Hosp Santa Creu and Sant Pau, Spain4 aut
700	1	a Molinuevo, Jose Luisu Clin Univ Hosp, Spain4 aut
700	1	a Jagust, William J.u Univ Calif Berkeley, CA 94720 USA4 aut
700	1	a Frisoni, Giovanni B.u Univ Hosp, Switzerland; Univ Hosp, Switzerland; Univ Geneva, Switzerland; IRCCS, Italy4 aut
700	1	a Ivanoiu, Adrianu Clin Univ Hosp, Spain; Catholic Univ Louvain, Belgium; Catholic Univ Louvain, Belgium4 aut
700	1	a Chetelat, Gaelu Univ Caen Normandie, France4 aut
700	1	a de Oliveira, Catarina Resendeu CHU Coimbra, Portugal4 aut
700	1	a Rodrigue, Karen M.u Univ Texas Dallas, TX USA4 aut
700	1	a Kornhuber, Johannesu Friedrich Alexander Univ Erlangen Nuremberg, Germany4 aut
700	1	a Wallin, Andersu Univ Gothenburg, Sweden4 aut
700	1	a Klimkowicz-Mrowiec, Aleksandrau Jagiellonian Univ, Poland4 aut
700	1	a Kandimalla, Rameshu Postgrad Inst Med Educ and Res PGIMER, India4 aut
700	1	a Popp, Juliusu Univ Hosp Lausanne, Switzerland4 aut
700	1	a Aalten, Pauline P.u Maastricht Univ, Netherlands4 aut
700	1	a Aarsland, Dagu Stavanger Univ Hosp, Norway4 aut
700	1	a Alcolea, Danielu Hosp Santa Creu and Sant Pau, Spain4 aut
700	1	a Almdahl, Ina S.u Akershus Univ Hosp, Norway4 aut
700	1	a Baldeiras, Inesu CHU Coimbra, Portugal4 aut
700	1	a van Buchem, Mark A.u Leiden Univ, Netherlands4 aut
700	1	a Cavedo, Enricau IRCCS, Italy; Univ Pierre and Marie Curie UPMC Paris 06, France4 aut
700	1	a Chen, Keweiu Banner Alzheimers Inst, AZ USA4 aut
700	1	a Cohen, Ann D.u Univ Pittsburgh, PA USA4 aut
700	1	a Foerster, Stefanu Tech Univ Munich, Germany4 aut
700	1	a Fortea, Juanu Hosp Santa Creu and Sant Pau, Spain4 aut
700	1	a Frederiksen, Kristian S.u Univ Copenhagen, Denmark4 aut
700	1	a Freund-Levi, Yvonneu Karolinska Univ, Sweden4 aut
700	1	a Gill, Kiran Dipu Postgrad Inst Med Educ and Res PGIMER, India4 aut
700	1	a Gkatzima, Olymbiau Aristotle Univ Thessaloniki, Greece4 aut
700	1	a Grimmer, Timou Techn Univ Munchen, Germany4 aut
700	1	a Hampel, Haraldu Univ Pierre and Marie Curie UPMC Paris 06, France; Ludwig Maximilians Univ Munchen, Germany; Ludwig Maximilians Univ Munchen, Germany4 aut
700	1	a Herukka, Sanna-Kaisau Univ Eastern Finland, Finland; Kuopio Univ Hosp, Finland4 aut
700	1	a Johannsen, Peteru Rigshosp, Denmark4 aut
700	1	a van Laere, Koenu Katholieke Univ Leuven, Belgium4 aut
700	1	a de Leon, Mony J.u NYU, NY USA4 aut
700	1	a Maier, Wolfgangu Univ Bonn, Germany4 aut
700	1	a Marcusson, Janu Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Medicinska och geriatriska akutkliniken4 aut0 (Swepub:liu)janma25
700	1	a Meulenbroek, Olgau Radboud Univ Nijmegen, Netherlands4 aut
700	1	a Mollergard, Hanne M.u Akershus Univ Hosp, Norway4 aut
700	1	a Morris, John C.u Washington Univ, MO 63110 USA4 aut
700	1	a Mroczko, Barbarau Med Univ Bialystok, Poland4 aut
700	1	a Nordlund, Artou Univ Gothenburg, Sweden4 aut
700	1	a Prabhakar, Sudeshu Postgrad Inst Med Educ and Res PGIMER, India4 aut
700	1	a Peters, Oliveru German Ctr Neurodegenerat Dis DZNE, Germany4 aut
700	1	a Rami, Lorenau Clin Univ Hosp, Spain4 aut
700	1	a Rodriguez-Rodriguez, Eloyu Univ Hosp Marques Valdecilla, Spain4 aut
700	1	a Roe, Catherine M.u Washington Univ, MO 63110 USA4 aut
700	1	a Ruther, Eckartu Georg August Univ, Germany4 aut
700	1	a Santana, Isabelu CHU Coimbra, Portugal4 aut
700	1	a Schroder, Johannesu Heidelberg Univ, Germany4 aut
700	1	a Seo, Sang W.u Sungkyunkwan Univ, South Korea4 aut
700	1	a Soininen, Hilkkau Univ Eastern Finland, Finland; Kuopio Univ Hosp, Finland4 aut
700	1	a Spiru, Luizau Carol Davila Univ Med and Pharm, Romania4 aut
700	1	a Stomrud, Eriku Lund Univ, Sweden4 aut
700	1	a Struyfs, Hanneu Univ Antwerp, Belgium4 aut
700	1	a Teunissen, Charlotte E.u Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands4 aut
700	1	a Verhey, Frans R. J.u Maastricht Univ, Netherlands4 aut
700	1	a Vos, Stephanie J. B.u Maastricht Univ, Netherlands4 aut
700	1	a van Doorn, Linda J. C. van Waalwijku Radboud Univ Nijmegen, Netherlands; Radboud Univ Nijmegen, Netherlands4 aut
700	1	a Waldemar, Gunhildu Univ Copenhagen, Denmark4 aut
700	1	a Wallin, Asa K.u Lund Univ, Sweden4 aut
700	1	a Wiltfang, Jensu Georg August Univ, Germany; Georg August Univ, Germany4 aut
700	1	a Vandenberghe, Riku Katholieke Univ Leuven, Belgium; Katholieke Univ Leuven, Belgium4 aut
700	1	a Brooks, David J.u Imperial Coll London, England4 aut
700	1	a Fladby, Tormodu Akershus Univ Hosp, Norway4 aut
700	1	a Rowe, Christopher C.u Austin Hlth, Australia; Austin Hlth, Australia4 aut
700	1	a Drzezga, Alexanderu Univ Cologne, Germany4 aut
700	1	a Verbeek, Marcel M.u Radboud Univ Nijmegen, Netherlands; Radboud Univ Nijmegen, Netherlands4 aut
700	1	a Sarazin, Marieu Sorbonne Paris Cite, France4 aut
700	1	a Wolk, David A.u Univ Penn, PA 19104 USA4 aut
700	1	a Fleisher, Adam S.u Banner Alzheimers Inst, AZ USA; Eli Lilly, IN USA; Univ Calif San Diego, CA 92103 USA4 aut
700	1	a Klunk, William E.u Univ Pittsburgh, PA USA4 aut
700	1	a Na, Duk L.u Sungkyunkwan Univ, South Korea4 aut
700	1	a Sanchez-Juan, Pascualu Univ Hosp Marques Valdecilla, Spain4 aut
700	1	a Lee, Dong Youngu Seoul Natl Univ, South Korea4 aut
700	1	a Nordberg, Agnetau Karolinska Univ Hosp, Sweden4 aut
700	1	a Tsolaki, Magdau Aristotle Univ Thessaloniki, Greece4 aut
700	1	a Camus, Vincentu Univ Francois Rabelais Tours, France4 aut
700	1	a Rinne, Juha O.u Univ Turku, Finland; Univ Turku, Finland; Turku Univ Hosp, Finland4 aut
700	1	a Fagan, Anne M.u Washington Univ, MO 63110 USA4 aut
700	1	a Zetterberg, Henriku UCL, England; UK Dementia Res Inst, England; Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden4 aut
700	1	a Blennow, Kaju Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden4 aut
700	1	a Rabinovici, Gil D.u Univ Calif San Francisco, CA 94143 USA4 aut
700	1	a Hansson, Oskaru Lund Univ, Sweden4 aut
700	1	a van Berckel, Bart N. M.u Vrije Univ Amsterdam, Netherlands4 aut
700	1	a van der Flier, Wiesje M.u Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands4 aut
700	1	a Scheltens, Philipu Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands4 aut
700	1	a Visser, Pieter Jelleu Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands; Maastricht Univ, Netherlands4 aut
700	1	a Ossenkoppele, Riku Lund Univ, Sweden; Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands4 aut
710	2	a Lund Univ, Swedenb Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands4 org
773	0	t Alzheimer's & Dementiad : ELSEVIER SCIENCE INCg 14:7, s. 913-924q 14:7<913-924x 1552-5260x 1552-5279
856	4	u https://lirias.kuleuven.be/bitstream/123456789/621579/1/1-s2.0-S1552526018300633-main.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-150288
856	4 8	u https://doi.org/10.1016/j.jalz.2018.02.009

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By the author/editor: Mattsson, Niklas; Groot, Colin; Jansen, Willemij ...; Landau, Susan M.; Villemagne, Vict ...; Engelborghs, Seb ...; show more...; Mintun, Mark M.; Lleo, Alberto; Molinuevo, Jose ...; Jagust, William ...; Frisoni, Giovann ...; Ivanoiu, Adrian; Chetelat, Gael; de Oliveira, Cat ...; Rodrigue, Karen ...; Kornhuber, Johan ...; Wallin, Anders; Klimkowicz-Mrowi ...; Kandimalla, Rame ...; Popp, Julius; Aalten, Pauline ...; Aarsland, Dag; Alcolea, Daniel; Almdahl, Ina S.; Baldeiras, Ines; van Buchem, Mark ...; Cavedo, Enrica; Chen, Kewei; Cohen, Ann D.; Foerster, Stefan; Fortea, Juan; Frederiksen, Kri ...; Freund-Levi, Yvo ...; Gill, Kiran Dip; Gkatzima, Olymbi ...; Grimmer, Timo; Hampel, Harald; Herukka, Sanna-K ...; Johannsen, Peter; van Laere, Koen; de Leon, Mony J.; Maier, Wolfgang; Marcusson, Jan; Meulenbroek, Olg ...; Mollergard, Hann ...; Morris, John C.; Mroczko, Barbara; Nordlund, Arto; Prabhakar, Sudes ...; Peters, Oliver; Rami, Lorena; Rodriguez-Rodrig ...; Roe, Catherine M ...; Ruther, Eckart; Santana, Isabel; Schroder, Johann ...; Seo, Sang W.; Soininen, Hilkka; Spiru, Luiza; Stomrud, Erik; Struyfs, Hanne; Teunissen, Charl ...; Verhey, Frans R. ...; Vos, Stephanie J ...; van Doorn, Linda ...; Waldemar, Gunhil ...; Wallin, Asa K.; Wiltfang, Jens; Vandenberghe, Ri ...; Brooks, David J.; Fladby, Tormod; Rowe, Christophe ...; Drzezga, Alexand ...; Verbeek, Marcel ...; Sarazin, Marie; Wolk, David A.; Fleisher, Adam S ...; Klunk, William E ...; Na, Duk L.; Sanchez-Juan, Pa ...; Lee, Dong Young; Nordberg, Agneta; Tsolaki, Magda; Camus, Vincent; Rinne, Juha O.; Fagan, Anne M.; Zetterberg, Henr ...; Blennow, Kaj; Rabinovici, Gil ...; Hansson, Oskar; van Berckel, Bar ...; van der Flier, W ...; Scheltens, Phili ...; Visser, Pieter J ...; Ossenkoppele, Ri ...; show less...

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