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Transitions in infant learning are modulated by dopamine in the amygdala

Barr, Gordon A (author)
Department of Anesthesiology and Critical Care Medicine, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA / Department of Developmental Neuroscience, New York State Psychiatric Institute, New York, New York, USA
Moriceau, Stephanie (author)
Department of Zoology, University of Oklahoma, Norman, Oklahoma, USA / Emotional Brain Institute, Nathan Kline Institute, Orangeburg, New York, USA / Child and Adolescent Psychiatry, New York University Langone Medical Center, New York, New York, USA
Shionoya, Kiseko, 1964- (author)
Department of Zoology, University of Oklahoma, Norman, Oklahoma, USA
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Muzny, Kyle (author)
Department of Zoology, University of Oklahoma, Norman, Oklahoma, USA
Gao, Puhong (author)
Department of Developmental Neuroscience, New York State Psychiatric Institute, New York, New York, USA
Wang, Shaoning (author)
Department of Anesthesiology and Critical Care Medicine, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA / Department of Developmental Neuroscience, New York State Psychiatric Institute, New York, New York, USA
Sullivan, Regina M (author)
Department of Zoology, University of Oklahoma, Norman, Oklahoma, USA / Emotional Brain Institute, Nathan Kline Institute, Orangeburg, New York, USA / Child and Adolescent Psychiatry, New York University Langone Medical Center, New York, New York, USA
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 (creator_code:org_t)
2009-09-27
2009
English.
In: Nature Neuroscience. - : Nature Publishing Group. - 1097-6256 .- 1546-1726. ; 12, s. 1367-1369
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Behavioral transitions characterize development. Young infant rats paradoxically prefer odors that are paired with shock, but older pups learn aversions. This transition is amygdala and corticosterone dependent. Using microarrays and microdialysis, we found downregulated dopaminergic presynaptic function in the amygdala with preference learning. Corticosterone-injected 8-d-old pups and untreated 12-d-old pups learned aversions and had dopaminergic upregulation in the amygdala. Dopamine injection into the amygdala changed preferences to aversions, whereas dopamine antagonism reinstated preference learning.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Annan medicin och hälsovetenskap (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Other Medical and Health Sciences (hsv//eng)

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