Search: onr:"swepub:oai:DiVA.org:liu-150505" >
ApoE facilitates th...
ApoE facilitates the microglial response to amyloid plaque pathology
-
- Ulrich, Jason D. (author)
- Washington Univ, MO 63110 USA; Washington Univ, MO 63130 USA; Washington Univ, MO 63130 USA
-
- Ulland, Tyler K. (author)
- Washington Univ, MO 63130 USA
-
- Mahan, Thomas E. (author)
- Washington Univ, MO 63110 USA; Washington Univ, MO 63130 USA; Washington Univ, MO 63130 USA
-
show more...
-
- Nyström, Sofie (author)
- Linköpings universitet,Kemi,Tekniska fakulteten
-
- Nilsson, Peter (author)
- Linköpings universitet,Kemi,Tekniska fakulteten
-
- Song, Wilbur M. (author)
- Washington Univ, MO 63130 USA
-
- Zhou, Yingyue (author)
- Washington Univ, MO 63130 USA
-
- Reinartz, Mariska (author)
- Washington Univ, MO 63110 USA; Radboud Univ Nijmegen, Netherlands
-
- Choi, Seulah (author)
- Washington Univ, MO 63110 USA; Washington Univ, MO 63130 USA; Washington Univ, MO 63130 USA
-
- Jiang, Hong (author)
- Washington Univ, MO 63110 USA; Washington Univ, MO 63130 USA; Washington Univ, MO 63130 USA
-
- Stewart, Floy R. (author)
- Washington Univ, MO 63110 USA; Washington Univ, MO 63130 USA; Washington Univ, MO 63130 USA
-
- Anderson, Elise (author)
- Washington Univ, MO 63110 USA; Washington Univ, MO 63130 USA; Washington Univ, MO 63130 USA
-
- Wang, Yaming (author)
- Washington Univ, MO 63130 USA; Eli Lilly and Co, IN 46285 USA
-
- Colonna, Marco (author)
- Washington Univ, MO 63130 USA
-
- Holtzman, David M. (author)
- Washington Univ, MO 63110 USA; Washington Univ, MO 63130 USA; Washington Univ, MO 63130 USA
-
show less...
-
(creator_code:org_t)
- 2018-02-26
- 2018
- English.
-
In: Journal of Experimental Medicine. - : ROCKEFELLER UNIV PRESS. - 0022-1007 .- 1540-9538. ; 215:4, s. 1047-1058
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://liu.diva-por... (primary) (Raw object)
-
https://rupress.org/...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- One of the hallmarks of Alzheimers disease is the presence of extracellular diffuse and fibrillar plaques predominantly consisting of the amyloid-beta (A beta) peptide. Apolipoprotein E (ApoE) influences the deposition of amyloid pathology through affecting the clearance and aggregation of monomeric A beta in the brain. In addition to influencing A beta metabolism, increasing evidence suggests that apoE influences microglial function in neurodegenerative diseases. Here, we characterize the impact that apoE has on amyloid pathology and the innate immune response in APPPS1 Delta E9 and APPPS1-21 transgenic mice. We report that Apoe deficiency reduced fibrillar plaque deposition, consistent with previous studies. However, fibrillar plaques in Apoe-deficient mice exhibited a striking reduction in plaque compaction. Hyperspectral fluorescent imaging using luminescent conjugated oligothiophenes identified distinct A beta morphotypes in Apoe-deficient mice. We also observed a significant reduction in fibrillar plaque-associated microgliosis and activated microglial gene expression in Apoe-deficient mice, along with significant increases in dystrophic neurites around fibrillar plaques. Our results suggest that apoE is critical in stimulating the innate immune response to amyloid pathology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Ulrich, Jason D.
-
Ulland, Tyler K.
-
Mahan, Thomas E.
-
Nyström, Sofie
-
Nilsson, Peter
-
Song, Wilbur M.
-
show more...
-
Zhou, Yingyue
-
Reinartz, Marisk ...
-
Choi, Seulah
-
Jiang, Hong
-
Stewart, Floy R.
-
Anderson, Elise
-
Wang, Yaming
-
Colonna, Marco
-
Holtzman, David ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
- Articles in the publication
-
Journal of Exper ...
- By the university
-
Linköping University