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Zinc Finger Protein...
Zinc Finger Protein 521 Regulates Early Hematopoiesis through Cell-Extrinsic Mechanisms in the Bone Marrow Microenvironment
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- Fleenor, Courtney J. (author)
- Natl Jewish Hlth, CO 80206 USA; Univ Colorado, CO 80045 USA; Globeimmune Inc, CO USA
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- Arends, Tessa (author)
- Univ Colorado, CO 80045 USA
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- Lei, Hong (author)
- Natl Jewish Hlth, CO 80206 USA; Univ Colorado, CO 80045 USA
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- Åhsberg, Josefine (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Okuyama, Kazuki (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Kuruvilla, Jacob (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Cristobal, Susana (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Rabe, Jennifer L. (author)
- Univ Colorado, CO 80045 USA
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- Pandey, Ahwan (author)
- Univ Colorado, CO USA; Univ Colorado, CO USA
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- Danhorn, Thomas (author)
- Natl Jewish Hlth, CO USA
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- Straign, Desiree (author)
- Natl Jewish Hlth, CO 80206 USA
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- Espinosa, Joaquin M. (author)
- Univ Colorado, CO USA; Univ Colorado, CO USA
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- Warming, Soren (author)
- Genentech Inc, CA 94080 USA
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- Pietras, Eric M. (author)
- Univ Colorado, CO USA
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- Sigvardsson, Mikael (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Hagman, James R. (author)
- Natl Jewish Hlth, CO 80206 USA; Univ Colorado, CO 80045 USA; Univ Colorado, CO 80045 USA
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(creator_code:org_t)
- AMER SOC MICROBIOLOGY, 2018
- 2018
- English.
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In: Molecular and Cellular Biology. - : AMER SOC MICROBIOLOGY. - 0270-7306 .- 1098-5549. ; 38:17
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Zinc finger protein 521 (ZFP521), a DNA-binding protein containing 30 Kruppel-like zinc fingers, has been implicated in the differentiation of multiple cell types, including hematopoietic stem and progenitor cells (HSPC) and B lymphocytes. Here, we report a novel role for ZFP521 in regulating the earliest stages of hematopoiesis and lymphoid cell development via a cell-extrinsic mechanism. Mice with inactivated Zfp521 genes (Zfp521(-/-)) possess reduced frequencies and numbers of hematopoietic stem and progenitor cells, common lymphoid progenitors, and B and T cell precursors. Notably, ZFP521 deficiency changes bone marrow microenvironment cytokine levels and gene expression within resident HSPC, consistent with a skewing of hematopoiesis away from lymphopoiesis. These results advance our understanding of ZFP521s role in normal hematopoiesis, justifying further research to assess its potential as a target for cancer therapies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- hematopoietic stem cell; ZFP521/ZNF521; lymphopoiesis; bone marrow microenvironment; hematopoietic progenitors
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Fleenor, Courtne ...
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Arends, Tessa
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Lei, Hong
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Åhsberg, Josefin ...
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Okuyama, Kazuki
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Kuruvilla, Jacob
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show more...
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Cristobal, Susan ...
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Rabe, Jennifer L ...
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Pandey, Ahwan
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Danhorn, Thomas
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Straign, Desiree
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Espinosa, Joaqui ...
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Warming, Soren
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Pietras, Eric M.
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Sigvardsson, Mik ...
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Hagman, James R.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Molecular and Ce ...
- By the university
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Linköping University